ANALYSIS OF INTERFERON-ALPHA-2 SEQUENCES IN HUMAN GENOMIC DNA

被引：17

作者：

GEWERT, D ^{[1
]}

SALOM, C ^{[1
]}

BARBER, K ^{[1
]}

MACBRIDE, S ^{[1
]}

COOPER, H ^{[1
]}

LEWIS, A ^{[1
]}

WOOD, J ^{[1
]}

CROWE, S ^{[1
]}

机构：

[1] WELLCOME FDN LTD,DIV MANAGEMENT SERV,BECKENHAM BR3 3BS,KENT,ENGLAND

来源：

JOURNAL OF INTERFERON RESEARCH | 1993年 / 13卷 / 03期

关键词：

D O I：

10.1089/jir.1993.13.227

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have analyzed the genomic DNA sequence corresponding to the human interferon-alpha2 (IFN-alpha2) gene locus. In human lymphoblastoid Namalwa cells, we have detected sequences corresponding to IFN-alpha2b and -2c, while in human KG-1 cells both IFN-alpha2a and -2b were present. However, in 100 independent IFN-alpha2 clones derived from 20 unrelated Caucasian volunteers, we found only sequences corresponding to IFN-alpha2b. Statistical analysis of this result suggests that the sequences corresponding to IFN-alpha2a and -2c are either rare allelic variants of this gene, occurring in only a minority of the Caucasian population, or are restricted to transformed cell lines.

引用

页码：227 / 231

页数：5

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