BCG-INDUCED PROTECTION IN GUINEA-PIGS VACCINATED AND CHALLENGED VIA THE RESPIRATORY ROUTE

被引：58

作者：

LAGRANDERIE, M ^{[1
]}

RAVISSE, P ^{[1
]}

MARCHAL, G ^{[1
]}

GHEORGHIU, M ^{[1
]}

BALASUBRAMANIAN, V ^{[1
]}

WEIGESHAUS, EH ^{[1
]}

SMITH, DW ^{[1
]}

机构：

[1] INST PASTEUR, DEPT PHYSIOPATHOL EXPTL, BCG LAB, 25 RUE DR ROUX, 75724 PARIS, FRANCE

来源：

TUBERCLE AND LUNG DISEASE | 1993年 / 74卷 / 01期

关键词：

D O I：

10.1016/0962-8479(93)90067-8

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Since studies on cellular immune responses have demonstrated the role of the mucosal lymphoid system of the respiratory tract, we have studied responses obtained from the local respiratory route, compared to the systemic intradermal route, of BCG immunization. Guinea pigs vaccinated with different doses of BCG via both routes served to follow lymphoid cell proliferation, hilar lymph node and lung BCG clearance, lung granuloma formation and protection induced after virulent challenge. Results demonstrate that the aerogenic route of vaccination with BCG has no harmful side-effects for the host. in comparison with the intradermal route of vaccination, aerogenic vaccination with 10(5) BCG cfu induced higher local cellular immune responses and a substantially improved protective effect.

引用

页码：38 / 46

页数：9

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