SELECTIVE BLOCKADE OF N-METHYL-D-ASPARTATE RECEPTOR FUNCTION BY THE NITRIC-OXIDE DONOR, NITROPRUSSIDE

被引：46

作者：

EAST, SJ ^{[1
]}

BATCHELOR, AM ^{[1
]}

GARTHWAITE, J ^{[1
]}

机构：

[1] UNIV LIVERPOOL,DEPT PHYSIOL,BROWNLOW HILL,POB 147,LIVERPOOL L69 3BX,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 1-2期

关键词：

CEREBELLUM; NMDA RECEPTORS; NITROPRUSSIDE; NITRIC OXIDE (NO); CGMP;

D O I：

10.1016/0014-2999(91)90021-H

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The N-methyl-D-aspartate (NMDA) receptor-mediated component of the synaptic response of cerebellar granule cells to mossy fibre stimulation was selectively inhibited by the nitric oxide (NO) donor, nitroprusside (nitroferricyanide). The direct depolarisation of granule cells induced by perfusion of NMDA was similarly reduced. However, these effects are unlikely to be caused by NO because, inter alia, they could not be replicated by other NO donors whereas ferricyanide was similarly effective.

引用

页码：119 / 121

页数：3

共 8 条

[1] SELECTIVE MODULATION OF NMDA RESPONSES BY REDUCTION AND OXIDATION [J].

AIZENMAN, E ;

LIPTON, SA ;

LORING, RH .

NEURON, 1989, 2 (03) :1257-1263

[2] SYNAPTIC ACTIVATION OF N-METHYL-D-ASPARTATE AND NON-N-METHYL-D-ASPARTATE RECEPTORS IN THE MOSSY FIBER PATHWAY IN ADULT AND IMMATURE RAT CEREBELLAR SLICES [J].

GARTHWAITE, J ;

BRODBELT, AR .

NEUROSCIENCE, 1989, 29 (02) :401-412

[3] CELLULAR-ORIGINS OF CYCLIC-GMP RESPONSES TO EXCITATORY AMINO-ACID RECEPTOR AGONISTS IN RAT CEREBELLUM INVITRO [J].

GARTHWAITE, J ;

GARTHWAITE, G .

JOURNAL OF NEUROCHEMISTRY, 1987, 48 (01) :29-39

[4] GLUTAMATE, NITRIC-OXIDE AND CELL CELL SIGNALING IN THE NERVOUS-SYSTEM [J].

GARTHWAITE, J .

TRENDS IN NEUROSCIENCES, 1991, 14 (02) :60-67

[5]

Jocelyn P. C., 1972, BIOCH SH GROUP OCCUR

[6] THE MECHANISMS BY WHICH HEMOGLOBIN INHIBITS THE RELAXATION OF RABBIT AORTA INDUCED BY NITROVASODILATORS, NITRIC-OXIDE, OR BOVINE RETRACTOR PENIS INHIBITORY FACTOR [J].

MARTIN, W ;

SMITH, JA ;

WHITE, DG .

BRITISH JOURNAL OF PHARMACOLOGY, 1986, 89 (03) :563-571

[7] BIOSYNTHESIS OF NITRIC-OXIDE FROM L-ARGININE - A PATHWAY FOR THE REGULATION OF CELL-FUNCTION AND COMMUNICATION [J].

MONCADA, S ;

PALMER, RMJ ;

HIGGS, EA .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (11) :1709-1715

[8] COMPARATIVE EFFECTS OF SOME NITRIC-OXIDE DONORS ON CYCLIC-GMP LEVELS IN RAT CEREBELLAR SLICES [J].

SOUTHAM, E ;

GARTHWAITE, J .

NEUROSCIENCE LETTERS, 1991, 130 (01) :107-111

← 1 →