ANTIGEN RECEPTOR-MEDIATED CALCIUM SIGNALS IN B-CELLS AS REVEALED BY CONFOCAL FLUORESCENCE MICROSCOPY

被引：26
|
作者：
YAMADA, H
MIZUGUCHI, J
NAKANISHI, M
机构：
[1] NAGOYA CITY UNIV,FAC PHARMACEUT SCI,TANABE DORI,MIZUHO KU,NAGOYA,AICHI 467,JAPAN
[2] NATL INST HLTH,DEPT APPL IMMUNOL,SINAGAWA KU,TOKYO 141,JAPAN
来源：
FEBS LETTERS | 1991年 / 284卷 / 02期
关键词：
CONFOCAL FLUORESCENCE MICROSCOPE; CALCIUM SIGNAL; NUCLEUS; B-CELL; ANTIGEN RECEPTOR;
D O I：
10.1016/0014-5793(91)80696-Z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A confocal fluorescence microscope was used to study the antigen receptor-mediated calcium signals in B cells. Anti-IgD binding to B lymphoma cells (BAL17) increased the intracellular calcium concentration with short lag times. Confocal fluorescence images of the fluo-3-loaded BAL17 cells showed that the intracellular calcium ion concentrations increased non-homogeneously, suggesting that the calcium signals transferred not only to the cytoplasm but also to the nucleus.
引用
收藏
页码：249 / 251
页数：3
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