MORPHINE SUPPRESSION OF SUBSTANTIA NIGRA ZONA RETICULATA NEURONS IN THE RAT - IMPLICATED ROLE FOR A NOVEL STRIATONIGRAL FEEDBACK MECHANISM

被引：35

作者：

FINNERTY, EP ^{[1
]}

CHAN, SHH ^{[1
]}

机构：

[1] INDIANA STATE UNIV,DEPT LIFE SCI,TERRE HAUTE,IN 47809

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 3-4期

关键词：

Caudate nucleus; Dopamine; Morphine; Naloxone; Rat; Substantia nigra;

D O I：

10.1016/0014-2999(79)90296-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In lightly anesthetized rats, systemic administration of morphine exerted a naloxone-reversible suppression of spontaneously discharging neurons located primarily in the substantia nigra zona reticula, either at rest or after their activation by microinjection into the caudate nucleus. Inactivation of these neurons within the striatonigral feedback pathway is suggested to complement a direct action on the nigrostriatal dopaminergic cells by the opiate, resulting the morphine suppression of caudate neuronal activities. © 1979.

引用

页码：307 / 310

页数：4

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