STUDIES ON ABSORPTION, DISTRIBUTION, EXCRETION AND METABOLISM OF GINSENG SAPONINS .5. THE DECOMPOSITION PRODUCTS OF GINSENOSIDE-RB2 IN THE LARGE-INTESTINE OF RATS

被引：58

作者：

KARIKURA, M ^{[1
]}

MIYASE, T ^{[1
]}

TANIZAWA, H ^{[1
]}

TAKINO, Y ^{[1
]}

TANIYAMA, T ^{[1
]}

HAYASHI, T ^{[1
]}

机构：

[1] KOSHIRO CO LTD, CHUO KU, OSAKA 541, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 10期

关键词：

1?C-NMR; ginseng saponin; ginsenoside Rb2; HPLC; metabolism; prosapogenin; rat large intestine; TLC;

D O I：

10.1248/cpb.38.2859

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The decomposition of ginsenoside Rb2 (Rb2) in the rat large intestine after oral administration was investigated in detail. A part of Rb2 was decomposed and six decomposition products (1—VI) were observed on thin-layer chromatogram. Among them, five products (I—V) were isolated, and identification of these compounds was done by carbon-13 nuclear magnetic resonance (13C-NMR). On the basis of 13C-NMR analysis, these compounds were identified as ginsenoside Rd (I), 3-0-/?-D-glucopyranosyl-2O-0-[a-L-arabinopyranosyl(l->6)-/f-D-glucopyranosyl]-2O(5)-proto-panaxadiol (II), ginsenoside F2 (III), 2O-0-[<x-L-arabinopyranosyl(l->6)-/f-D-glucopyranosyl]-2O(S ‘)-protopanaxadiol (IV), and compound K (V), respectively. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2859 / 2861

页数：3

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