PITUITARY-GONADAL FUNCTION IN WOMEN FOLLOWING CYCLOPHOSPHAMIDE TREATMENT FOR CHILDHOOD NEPHROTIC SYNDROME - LONG-TERM FOLLOW-UP-STUDY

被引：10
作者：
BOGDANOVIC, R
BANICEVIC, M
CVORIC, A
机构：
[1] Institute for Mother and Child Health Care of Serbia, Belgrade, YU-11071
来源：
PEDIATRIC NEPHROLOGY | 1990年 / 4卷 / 05期
关键词：
CYCLOPHOSPHAMIDE; OVARIAN FUNCTION; CHILDHOOD NEPHROTIC SYNDROME;
D O I：
10.1007/BF00869819
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Ovarian and pituitary-gonadal function was evaluated in 12 women who were treated with cyclophosphamide for nephrotic syndrome before or during puberty. The mean age at the start of treatment was 8.7 years; the mean total dose of cyclophsophamide was 439 mg/kg body weight; and the mean follow-up time was 12.3 years. The investigations included detailed developmental, menstrual and fertility histories; general and gynaecological examinations; basal levels and follicle-stimulating hormone and luteinizing hormone responses to gonadotropin-releasing hormone, and plasma oestradiol determinations. All patients had normal pubertal development and regular menstrual patterns. Two had borne healthy children. Although hormonal studies did not show obvious ovarian or pituitary-gonadal dysfunction, further follow-up is required to ascertain whether the patients with the most prolonged treatment undergo a premature menopause.
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收藏
页码：455 / 458
页数：4
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