IMMUNOHISTOCHEMICAL LOCALIZATION OF PARATHYROID HORMONE-RELATED PROTEIN IN PARATHYROID ADENOMA AND HYPERPLASIA

被引：58

作者：

DANKS, JA

EBELING, PR

HAYMAN, JA

DIEFENBACHJAGGER, H

COLLIER, FM

GRILL, V

SOUTHBY, J

MOSELEY, JM

CHOU, ST

MARTIN, TJ

机构：

[1] ST VINCENTS HOSP,ST VINCENTS INST MED RES,41 VICTORIA PARADE,MELBOURNE 3065,AUSTRALIA

[2] UNIV MELBOURNE,REPATRIAT HOSP,DEPT PATHOL,HEIDELBERG,VIC 3081,AUSTRALIA

[3] REPATRIAT GEN HOSP,DEPT ANAT PATHOL,HEIDELBERG 3081,AUSTRALIA

[4] UNIV MELBOURNE,ST VINCENT HOSP,DEPT MED,MELBOURNE 3065,AUSTRALIA

来源：

JOURNAL OF PATHOLOGY | 1990年 / 161卷 / 01期

关键词：

Hypercalcaemia; hyperparathyroidism; parathyroid adenomata; parathyroid hyperplasia;

D O I：

10.1002/path.1711610106

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Parathyroid hormone‐related protein (PTHrP) is invoked as the cause of humoral hypercalcaemia of malignancy (HHM); it is contained in the keratinocyte layer of normal skin; and there is evidence that is is produced by fetal parathyroids. Antibodies against synthetic PTHrP peptides have been raised in rabbits and sheep. This immunohisto‐chemical study has found that primary parathyroid adenomata and hyperplastic glands from patients with chronic renal failure stain positively with antisera against PTHrP(1–34) and PTHrP(50–69). Primary hyperplastic glands are negative. No staining with anti‐PTHrP(106–141) antiserum could be detected immunohistochemically in any of the parathyroid adenomata or hyperplasia. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：27 / 33

页数：7

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