Separation of enantiomers by supercritical fluid chromatography on polysaccharide derivative- based chiral stationary phases

被引:4
作者
Li Dongyan [1 ]
Wu Xi [1 ]
Hao Fangli [1 ]
Yang Yang [1 ]
Chen Xiaoming [1 ]
机构
[1] Daicel Chiral Technol China Co Ltd, Shanghai 200131, Peoples R China
关键词
supercritical fluid chromatography (SFC); chiral separation; chiral stationary phase; polysaccharide derivatives;
D O I
10.3724/SP.J.1123.2015.10039
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Eleven kinds of chiral compounds have been well separated within 10 min on polysaccharide derivative-based chiral stationary phases named Chiralpak IA, IB, IC, ID, IE and IF by supercritical fluid chromatography (SFC). The chiral recognition of these chiral compounds has demonstrated good complementary enantioselectivities of the six chiral columns, which were proved to be useful for chiral SFC. Both the elution time and enantioselectivies could be significantly affected by the modifier types and their concentrations, such as methanol, ethanol and isopropanol, which should be optimized during the experiments. In addition, the solvent versatility of the immobilized chiral stationary phase on the optimization of the chiral separation was helpful.
引用
收藏
页码:80 / 84
页数:5
相关论文
共 12 条
[1]   Enantioselective chromatography as a powerful alternative for the preparation of drug enantiomers [J].
Francotte, ER .
JOURNAL OF CHROMATOGRAPHY A, 2001, 906 (1-2) :379-397
[2]  
[金薇 Jin Wei], 2013, [药物分析杂志, Chinese Journal of Pharmaceutical Analysis], V33, P822
[3]   On the method development of immobilized polysaccharide chiral stationary phases in supercritical fluid chromatography using an extended range of modifiers [J].
Lee, James ;
Lee, J. T. ;
Watts, William L. ;
Barendt, Joseph ;
Yan, Tony Q. ;
Huang, Yun ;
Riley, Frank ;
Hardink, Mark ;
Bradow, Jim ;
Franco, Pilar .
JOURNAL OF CHROMATOGRAPHY A, 2014, 1374 :238-246
[4]   Preparative enantioseparations using supercritical fluid chromatography [J].
Miller, Larry .
JOURNAL OF CHROMATOGRAPHY A, 2012, 1250 :250-255
[5]  
Okamoto Y, 1998, ANGEW CHEM INT EDIT, V37, P1020, DOI 10.1002/(SICI)1521-3773(19980504)37:8<1020::AID-ANIE1020>3.0.CO
[6]  
2-5
[7]  
Ren QL, 2000, CHINESE J ANAL CHEM, V28, P772
[8]   Enantioseparations in super- and subcritical fluid chromatography [J].
Terfloth, G .
JOURNAL OF CHROMATOGRAPHY A, 2001, 906 (1-2) :301-307
[9]   Chiral Separations: A Review of Current Topics and Trends [J].
Ward, Timothy J. ;
Ward, Karen D. .
ANALYTICAL CHEMISTRY, 2012, 84 (02) :626-635
[10]  
Wu J, 2004, PROGR PHARM SCI, V28, P300