MAMMARY CANCER INDUCTION BY 7,12-DIMETHYLBENZ(A)ANTHRACENE - RELATION TO AGE

被引：64

作者：

DAO, TL

机构：

[1] Department of Breast Surgery, Roswell Park Memorial Institute, New York State Department of Health, Bufalo

来源：

SCIENCE | 1969年 / 165卷 / 3895期

关键词：

D O I：

10.1126/science.165.3895.810

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mammary glands were transplanted from donors treated with 7,12-dimethylbenz(a)anthracene to untreated isologous recipients. Incidence of mammary tumors in mammary grafts from 56-day-old donors was significantly higher than that in grafts from 120-day-old donors, regardless of the age of the recipient hosts. When mammary glands were transplanted from untreated donors to isologous recipients that subsequently received 7,12-dimethylbenz(a)anthracene, a similar difference water. At the time of transplantation, in tumor incidence in the grafts was observed. In contrast to mammary glands of older females, mammary glands of young adult female rats are highly vulnerable to the carcinogenic of 7,12-dimethylbenz(a)anthracene.

引用

页码：810 / &