ANTIOXIDANT PROPERTIES OF PHENYL STYRYL KETONES

被引：21

作者：

RAJAKUMAR, DV ^{[1
]}

RAO, MNA ^{[1
]}

机构：

[1] COLL PHARMACEUT SCI, DEPT PHARMACEUT CHEM, MANIPAL 576119, INDIA

来源：

FREE RADICAL RESEARCH | 1995年 / 22卷 / 04期

关键词：

PHENYL STYRYL KETONE; ANTIOXIDANT; PEROXIDATION INHIBITOR;

D O I：

10.3109/10715769509145643

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenolic and non phenolic derivatives of phenyl styryl ketones were synthesized and evaluated as in vitro inhibitors of iron and cumene hydroperoxide dependent lipid peroxidation in rat brain homogenates. The compounds were also tested for antioxidant activity in phosphatidylcholine liposomes. Phenyl 3,5-di-tert-butyl-4-hydroxystyryl ketone was found to be the most potent inhibitor of peroxidation among all the compounds tested. It was found to be more active than vitamin E. It also reduced the stable free radical 1,1-diphenyl-2-picrylhydrazyl to an appreciable extent.

引用

页码：309 / 317

页数：9

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