INTERPRETATION OF A SIMPLE PCR ANALYSIS OF THE CYP2D6(A) AND CYP2DG(B) NULL ALLELES ASSOCIATED WITH THE DEBRISOQUINE SPARTEINE GENETIC-POLYMORPHISM

被引：26
作者：
DOUGLAS, AM [1 ]
ATCHISON, BA [1 ]
SOMOGYI, AA [1 ]
DRUMMER, OH [1 ]
机构：
[1] UNIV ADELAIDE, DEPT CLIN & EXPTL PHARMACOL, ADELAIDE, SA, AUSTRALIA
来源：
PHARMACOGENETICS | 1994年 / 4卷 / 03期
关键词：
D O I：
10.1097/00008571-199406000-00006
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
[No abstract available]
引用
收藏
页码：154 / 158
页数：5
相关论文
共 11 条
[1]  
ALLEN RC, 1989, BIOTECHNIQUES, V7, P736
[2]   CLINICAL-SIGNIFICANCE OF THE SPARTEINE-DEBRISOQUINE OXIDATION POLYMORPHISM [J].
BROSEN, K ;
GRAM, LF .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 36 (06) :537-547
[3]   DETECTION OF SICKLE-CELL-ANEMIA AND THALASSEMIAS [J].
CHEHAB, FF ;
DOHERTY, M ;
CAI, S ;
KAN, YW ;
COOPER, S ;
RUBIN, EM .
NATURE, 1987, 329 (6137) :293-294
[4]   SIMULTANEOUS DETERMINATION OF DEXTROMETHORPHAN AND 3 METABOLITES IN PLASMA AND URINE USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH APPLICATION TO THEIR DISPOSITION IN MAN [J].
CHEN, ZR ;
SOMOGYI, AA ;
BOCHNER, F .
THERAPEUTIC DRUG MONITORING, 1990, 12 (01) :97-104
[5]  
EVANS WE, 1991, PHARMACOGENETICS, V1, P143
[6]   IDENTIFICATION OF THE PRIMARY GENE DEFECT AT THE CYTOCHROME-P450 CYP2D LOCUS [J].
GOUGH, AC ;
MILES, JS ;
SPURR, NK ;
MOSS, JE ;
GAEDIGK, A ;
EICHELBAUM, M ;
WOLF, CR .
NATURE, 1990, 347 (6295) :773-776
[7]   GENOTYPING OF POOR METABOLIZERS OF DEBRISOQUINE BY ALLELE-SPECIFIC PCR AMPLIFICATION [J].
HEIM, M ;
MEYER, UA .
LANCET, 1990, 336 (8714) :529-532
[8]  
KIMURA S, 1989, AM J HUM GENET, V45, P889
[9]  
SEANWALSH P, 1991, BIOTECHNIQUES, V10, P506
[10]   DEBRISOQUINE HYDROXYLASE GENE POLYMORPHISM AND SUSCEPTIBILITY TO PARKINSONS-DISEASE [J].
SMITH, CAD ;
GOUGH, AC ;
LEIGH, PN ;
SUMMERS, BA ;
HARDING, AE ;
MARANGANORE, DM ;
STURMAN, SG ;
SCHAPIRA, AHV ;
WILLIAMS, AC ;
SPURR, NK ;
WOLF, CR .
LANCET, 1992, 339 (8806) :1375-1377
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