DOPA-DECARBOXYLATION IN THE STRIATA OF RATS WITH UNILATERAL SUBSTANTIA-NIGRA LESIONS

被引：31

作者：

KANG, UJ ^{[1
]}

PARK, DH ^{[1
]}

WESSEL, T ^{[1
]}

BAKER, H ^{[1
]}

JOH, TH ^{[1
]}

机构：

[1] CORNELL UNIV, COLL MED, BURKE MED RES INST, WHITE PLAINS, NY 10605 USA

来源：

NEUROSCIENCE LETTERS | 1992年 / 147卷 / 01期

关键词：

AROMATIC L-AMINO ACID DECARBOXYLASE; DOPA DECARBOXYLASE; PARKINSONS DISEASE; L-DOPA; 6-HYDROXYDOPAMINE; STRIATUM;

D O I：

10.1016/0304-3940(92)90773-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The source and site of the DOPA decarboxylation to dopamine in Parkinson's disease (PD) and animal models of PD are controversial. Since most of aromatic L-amino acid decarboxylase (AADC) are lost along with the degenerating dopaminergic neurons. we addressed the possibility that other decarboxylases or a novel protein that is structurally different from AADC decarboxylate L-DOPA in the denervated striatum. Immunotitration of the extracts from the denervated striatum with AADC antibody showed that all activity can be attributed to AADC-immunoreactive protein. We then investigated if there are non-dopaminergic intrinsic striatal neurons that express AADC. No evidence of such neurons was noted by immunocytochemistry and in situ hybridization.

引用

页码：53 / 57

页数：5

共 25 条

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