IRON CHELATING-AGENTS WITH CLINICAL POTENTIAL

被引:39
作者
HIDER, RC [1 ]
SINGH, S [1 ]
PORTER, JB [1 ]
机构
[1] UNIV COLL HOSP LONDON,SCH MED,DEPT HAEMATOL,WC1 LONDON,ENGLAND
来源
PROCEEDINGS OF THE ROYAL SOCIETY OF EDINBURGH SECTION B-BIOLOGICAL SCIENCES | 1992年 / 99卷
关键词
D O I
10.1017/S0269727000013117
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Iron is a critically important metal for a wide variety of cellular events. The element holds this central position by virtue of its facile redox chemistry and the high affinity of both redox states (iron II and iron III) for oxygen. These same properties also render iron toxic when levels exceed the normal binding capacity of the cell. As a result of this potential toxicity, selective iron chelators are finding an important role in the treatment of iron overload associated with many forms of thalassaemia. In addition, they appear to have potential in treating situations where a local increase in iron concentration causes an unfavourable pathology, for instance, in reperfused tissue (heart disease and stroke) and in Parkinsonian brain. There is also evidence that iron chelators may minimise the toxicity of paraquat and the side effects of bleomycin and doxorubicin. Non-haem iron enzymes can also be inhibited by iron chelators and consequently such enzymes as ribonucleotide reductase and lipoxygenase can be selectively inhibited. Such inhibitory action is being investigated for the treatment of malaria, neoplastic disease, psoriasis and asthma. Recent developments in these areas are discussed in the present overview.
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页码:137 / 168
页数:32
相关论文
共 123 条
[1]   PARKINSONS-DISEASE - PATHOPHYSIOLOGY [J].
AGID, Y .
LANCET, 1991, 337 (8753) :1321-1324
[2]   STUDIES OF THE SOLUTION STRUCTURE OF THE BLEOMYCIN-A2 IRON(II) CARBON-MONOXIDE COMPLEX BY MEANS OF 2-DIMENSIONAL NMR-SPECTROSCOPY AND DISTANCE GEOMETRY CALCULATIONS [J].
AKKERMAN, MAJ ;
NEIJMAN, EWJF ;
WIJMENGA, SS ;
HILBERS, CW ;
BERMEL, W .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (21) :7462-7474
[3]   A QUANTITATIVE STUDY ON NIGRO-NEOSTRIATAL DOPAMINE NEURON SYSTEM IN RAT [J].
ANDEN, NE ;
FUXE, K ;
HAMBERGER, B ;
HOKFELT, T .
ACTA PHYSIOLOGICA SCANDINAVICA, 1966, 67 (3-4) :306-+
[4]   EFFECT OF IRON CHELATION ON INFLAMMATORY JOINT DISEASE [J].
ANDREWS, FJ ;
MORRIS, CJ ;
KONDRATOWICZ, G ;
BLAKE, DR .
ANNALS OF THE RHEUMATIC DISEASES, 1987, 46 (04) :327-333
[5]   RAZOXANE (ICRF-159) IN THE TREATMENT OF PSORIASIS [J].
ATHERTON, DJ ;
WELLS, RS ;
LAURENT, MR ;
WILLIAMS, YF .
BRITISH JOURNAL OF DERMATOLOGY, 1980, 102 (03) :307-317
[6]  
AUST SD, 1988, OXYGEN RADICALS TISS, P27
[7]  
AUST SD, 1985, ADV FREE RADICAL BIO, V1, P1
[8]  
BARTLETT AN, 1990, BRIT J HAEMATOL, V76, P301, DOI 10.1111/j.1365-2141.1990.tb07888.x
[9]   APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].
BECKMAN, JS ;
BECKMAN, TW ;
CHEN, J ;
MARSHALL, PA ;
FREEMAN, BA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1620-1624
[10]  
BECTON DL, 1988, CANCER RES, V48, P7189