MOLECULAR-CLONING OF BOVINE ACTIN-LIKE PROTEIN, ACTIN2

被引：32

作者：

TANAKA, T

SHIBASAKI, F

ISHIKAWA, M

HIRANO, N

SAKAI, R

NISHIDA, J

TAKENAWA, T

HIRAI, H

机构：

[1] TOKYO METROPOLITAN GERIATR HOSP & INST GERONTOL,DEPT BIOSIGNAL RES,ITABASHI KU,TOKYO 173,JAPAN

[2] KIRIN BREWERY CO LTD,PHARMACEUT RES LAB,MAEBASHI,GUNMA 371,JAPAN

[3] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 3,BUNKYO KU,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91299-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Actins are major cytoskeletal components and highly conserved in evolution. In mammals, there are six actin isoforms, a pair of which shows at least 93% identity in the amino acid sequence. We have cloned cDNA for a bovine protein that is distantly related to members of the mammalian actin isotypes. The predicted amino acid sequence (418 residues long, calculated molecular mass 47369) shows that this protein, which we have named actin2, exhibits 36% identity to mammalian actins and 60% identity to the yeast actin-like protein, act2. We have concluded that actin2 defines a new class of mammalian actin-like proteins. It was also revealed that actin2 messenger RNA is expressed in a broad range of tissues. © 1992.

引用

页码：1022 / 1028

页数：7

共 13 条

[1]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

[2] STRUCTURE, CHROMOSOME LOCATION, AND EXPRESSION OF THE HUMAN GAMMA-ACTIN GENE - DIFFERENTIAL EVOLUTION, LOCATION, AND EXPRESSION OF THE CYTOSKELETAL BETA-ACTIN AND GAMMA-ACTIN GENES [J].