SYNTHESIS OF FUNCTIONALLY TETHERED OLIGODEOXYNUCLEOTIDES BY THE CONVERTIBLE NUCLEOSIDE APPROACH

被引：117

作者：

MACMILLAN, AM ^{[1
]}

VERDINE, GL ^{[1
]}

机构：

[1] HARVARD UNIV,DEPT CHEM,12 OXFORD ST,CAMBRIDGE,MA 02138

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 24期

关键词：

D O I：

10.1021/jo00311a005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

: A novel approach to the synthesis of oligodeoxynucleotides bearing tethered nonnative functional groups is reported. In this convertible nucleoside approach, the tether is installed at the final step of DNA synthesis, thus allowing the synthesis of a series of functionally tethered oligodeoxynucleotides from a single precursor. © 1990, American Chemical Society. All rights reserved.

引用

页码：5931 / 5933

页数：3

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