CONCENTRATIONS OF TYROSINE, L-DIHYDROXYPHENYLALANINE, DOPAMINE, AND 3-O-METHYLDOPA IN THE CEREBROSPINAL-FLUID OF PARKINSONS-DISEASE

被引：15
作者：
TOHGI, H
ABE, T
TAKAHASHI, S
NOZAKI, Y
KIKUCHI, T
机构：
[1] Department of Neurology, Iwate Medical University, Morioka
来源：
NEUROSCIENCE LETTERS | 1991年 / 127卷 / 02期
关键词：
PARKINSONS DISEASE; TYROSINE; 3,4-DIHYDROXYPHENYLALANINE; DOPAMINE; 3-O-METHYLDOPA; CEREBROSPINAL FLUID;
D O I：
10.1016/0304-3940(91)90796-V
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We determined the concentrations of tyrosine, L-3,4-dihydroxyphenylalanine (DOPA), dopamine (DA), and 3-O-methyldopa (3-OMD) in the cerebrospinal fluid (CSF) of parkinsonian patients and evaluated potential interactions between the substances. We found a significant increase in tyrosine, and a significant decrease in DOPA, DA, and 3-OMD. We also found that for a given concentration of DOPA, DA and 3-OMD were proportional. In addition, the ratio of DA to 3-OMD was significantly shifted in favor of DA in parkinsonian patients.
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收藏
页码：212 / 214
页数：3
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