PASSIVE SMOKING AND CHILDHOOD ASTHMA - URINARY COTININE LEVELS IN CHILDREN WITH ASTHMA AND IN REFERENTS

被引：43

作者：

WILLERS, S

SVENONIUS, E

SKARPING, G

机构：

[1] UNIV LUND,MALMO GEN HOSP,DEPT PEDIAT,S-21401 MALMO,SWEDEN

[2] UNIV LUND HOSP,DEPT OCCUPAT & ENVIRONM MED,S-22185 LUND,SWEDEN

来源：

ALLERGY | 1991年 / 46卷 / 05期

关键词：

CHILDHOOD ASTHMA; COTININE; INVOLUNTARY; PASSIVE SMOKING; PREDISPOSING FACTOR;

D O I：

10.1111/j.1398-9995.1991.tb00595.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Passive exposure to tobacco smoke as assessed in children with asthma (age 3-15) and in referents. There was statistically significantly (P < 0.0005) higher, excretion of the nicotine metabolite, cotinine, in the urine of 49 children with asthma (geometric mean 10 ng/ml) compared with 77 referents (4.8 ng/ml). Maternal smoking as statistically significantly more prevalent among the asthmatics than among the referents (relative risk = RR - 2.6, 95% Cl - 1.2-5.3). In conclusion, the exposure to environmental tobacco smoke in asthmatic children was higher than among healthy children, indicating that passive smoking may be a predisposing and/or aggravating factor for childhood asthma.

引用

页码：330 / 334

页数：5

共 20 条

[1] INTERACTION OF IMMUNOGLOBULIN-E AND CIGARETTE-SMOKE - PREDISPOSITION TO SYMPTOMATIC LUNG-DISEASE [J].