INFLUENCE OF NEONATAL HYPO-THYROIDISM ON THE DEVELOPMENT OF KETONE-BODY-METABOLIZING ENZYMES IN RAT-BRAIN

被引：22
作者：
PATEL, MS
机构：
[1] TEMPLE UNIV HOSP,FELS RES INST,GEN CLIN RES CTR,DEPT MED,PHILADELPHIA,PA 19140
[2] TEMPLE UNIV HOSP,FELS RES INST,GEN CLIN RES CTR,DEPT MED,PHILADELPHIA,PA 19140
来源：
BIOCHEMICAL JOURNAL | 1979年 / 184卷 / 01期
关键词：
D O I：
10.1042/bj1840169
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neonatal hypothyroidism markedly retarded the postnatal development of three ketone-body-metabolizing enzymes in rat brain during the first 4 weeks after birth. In contrast with normal animals, the brains of hypothyroid rats did not show decreases in the activities of these enzymes during the immediate postweaning period. The activities of ketone-body-oxidizing enzymes were markedly diminished in both non-synaptic and synaptic mitochondira isolated from 4-week-old hypothyroid rats compared with age-matched normal animals.
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页码：169 / 172
页数：4
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