FUNCTIONAL DECLINE IN HUNTINGTONS-DISEASE

被引：80

作者：

FEIGIN, A

KIEBURTZ, K

BORDWELL, K

COMO, P

STEINBERG, K

SOTACK, J

ZIMMERMAN, C

HICKEY, C

ORME, C

SHOULSON, I

机构：

[1] Department of Neurology, University of Rochester Medical Center, Rochester, New York

来源：

MOVEMENT DISORDERS | 1995年 / 10卷 / 02期

关键词：

HUNTINGTONS DISEASE; RATE OF PROGRESSION; CLINICAL FEATURES;

D O I：

10.1002/mds.870100213

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We prospectively evaluated 129 patients with manifest Huntington's disease (HD) to determine the rate of illness progression and the clinical features that correlate with functional decline. A single examiner evaluated each patient using the HD Functional Capacity Scale. Standardized motor performance was also assessed in 94 of the patients (73%) using the HD Rating Scale. Total Functional Capacity declined at a rate of 0.63 +/- 0.75 U per year. As functional capacity worsened, chorea lessened, and dystonia intensified. There was no correlation between rate of functional decline and age at onset of HD, body weight, gender of affected parent, or history of neuroleptic use.

引用

页码：211 / 214

页数：4

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