CELLULAR AND MOLECULAR ABNORMALITIES IN THE VASCULAR ENDOTHELIUM OF DIABETES-MELLITUS

被引：120

作者：

KING, GL ^{[1
]}

SHIBA, T ^{[1
]}

OLIVER, J ^{[1
]}

INOGUCHI, T ^{[1
]}

BURSELL, SE ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02215

来源：

ANNUAL REVIEW OF MEDICINE | 1994年 / 45卷

关键词：

ENDOTHELIAL CELLS; HYPERGLYCEMIA; DIACYLGLYCEROL/PROTEIN KINASE C; POLYOL; GLYCOSYLATION;

D O I：

10.1146/annurev.med.45.1.179

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Diabetic vascular complications affect both micro- and macrovasculature, primarily in the retina, renal glomeruli, and multiple sites in the macrovessels. This review presents a summary of the abnormal function found in vivo and in cultured vascular cells exposed to elevated levels of glucose. We also discuss the various biochemical hypotheses that have been proposed to explain the adverse effects of hyperglycemia on vascular cells.

引用

页码：179 / 188

页数：10

共 40 条

[1] AN ACTIVATED FORM OF TRANSFORMING GROWTH FACTOR-BETA IS PRODUCED BY COCULTURES OF ENDOTHELIAL-CELLS AND PERICYTES [J].