Acute Lymphoblastic Leukemia in a Man Treated With Fingolimod for Relapsing Multiple Sclerosis

被引：7

作者：

Cohan, Stanley ^{[1
]}

Godwin, John ^{[1
]}

Gaedeke, Leah ^{[1
]}

机构：

[1] Providence Hlth & Serv, 9427 SW Barnes Rd, Portland, OR 97225 USA

来源：

JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS | 2015年 / 3卷 / 01期

关键词：

relapsing multiple sclerosis; fingolimod; disease-modifying therapy; lymphoblastic leukemia;

D O I：

10.1177/2324709615575551

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A man with relapsing multiple sclerosis, treated with fingolimod 0.5 mg/d for 15 months, developed acute lymphoblastic leukemia and died 4 months after immune ablation and bone marrow allograft, from graft versus host disease. To our knowledge, this is the first case of acute lymphoblastic leukemia reported in a patient treated with fingolimod. Although no causal relationship can be established between fingolimod use and acute lymphoblastic leukemia risk in this single case, future surveillance for lymphatic cell malignancies in patients treated with fingolimod appears justified.

引用

页码：1 / 2

页数：2

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