PROTEIN KINASES .4. PROTEIN-KINASE CK2 - AN ENZYME WITH MULTIPLE SUBSTRATES AND A PUZZLING REGULATION

被引：584

作者：

ALLENDE, JE ^{[1
]}

ALLENDE, CC ^{[1
]}

机构：

[1] UNIV CHILE, FAC CIENCIAS, DEPT BIOL, SANTIAGO 7, CHILE

来源：

FASEB JOURNAL | 1995年 / 9卷 / 05期

关键词：

PROTEIN SUBSTRATE; CONSERVED REGION; AUTOPHOSPHORYLATION; ZINC FINGER; DESTRUCTION BOX;

D O I：

10.1096/fasebj.9.5.7896000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein kinase CK2 (also known as casein kinase II) is a ubiquitous eukaryotic ser/thr protein kinase present in the nucleus and cytoplasm. CK2 is known to phosphorylate more than 100 substrates, many of which are involved in the control of cell division and in signal transduction. The review centers on the structure and function of CK2 alpha and beta subunits and on the regulation of its activity, a topic that remains to be elucidated. An analogy is drawn between CK2 and the cyclin-dependent kinases (cdks); both types of protein kinases share many substrates and are activated by regulatory subunits.

引用

页码：313 / 323

页数：11

共 86 条

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