MAPPING OF ORNITHINE AMINOTRANSFERASE GENE-SEQUENCES TO MOUSE CHROMOSOME-7, CHROMOSOME-X, AND CHROMOSOME-3

被引：11
作者：
RAMESH, V
CHENG, SV
KOZAK, CA
HERRON, BJ
SHIH, VE
TAYLOR, BA
GUSELLA, JF
机构：
[1] MASSACHUSETTS GEN HOSP,MOLEC NEUROGENET LAB,BOSTON,MA 02129
[2] MASSACHUSETTS GEN HOSP,NEUROL SERV,AMINO ACID DISORDER LAB,BOSTON,MA 02129
[3] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892
[4] JACKSON LAB,BAR HARBOR,ME 04609
来源：
MAMMALIAN GENOME | 1992年 / 3卷 / 01期
关键词：
D O I：
10.1007/BF00355836
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ornithine aminotransferase (OAT), a mitochondrial matrix enzyme, is deficient in patients with gyrate atrophy of the choroid and retina. In human, the OAT structural gene maps to Chromosome (Chr) 10q26 and several OAT-related sequences, some of which are known to be processed pseudogenes, which map to Xp11.3-11.21. Here, we report chromosomal localization in the mouse of the OAT gene and related sequences. Genomic DNA blot analysis of a well-characterized panel of Chinese hamster x mouse somatic cell hybrids using a human OAT probe revealed two murine loci, one on mouse Chr 7 and the other on Chr X. In addition, segregation of restriction fragment length polymorphisms (RFLPs) detected by the OAT probe in recombinant inbred (RI) strains detected a third locus on Chr 3 and positioned the X locus near Cf-8 and Rsvp. Progeny of an intersubspecific back-cross were used to map the Chr 7 locus between Tyr and Int-2, near Cyp2e-1.
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收藏
页码：17 / 22
页数：6
相关论文
共 32 条
[1]  
AMAR L C, 1988, Genomics, V2, P220, DOI 10.1016/0888-7543(88)90006-7
[2]   CHARACTERIZATION OF A PANEL OF SOMATIC-CELL HYBRIDS FOR REGIONAL MAPPING OF THE MOUSE X-CHROMOSOME [J].
AVNER, P ;
ARNAUD, D ;
AMAR, L ;
CAMBROU, J ;
WINKING, H ;
RUSSELL, LB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (15) :5330-5334
[3]  
BARRETT DJ, 1987, INVEST OPHTH VIS SCI, V28, P1037
[4]   COMPARATIVE MAPPING OF DNA MARKERS FROM THE FAMILIAL ALZHEIMER-DISEASE AND DOWN SYNDROME REGIONS OF HUMAN CHROMOSOME-21 TO MOUSE CHROMOSOME-16 AND CHROMOSOME-17 [J].
CHENG, SV ;
NADEAU, JH ;
TANZI, RE ;
WATKINS, PC ;
JAGADESH, J ;
TAYLOR, BA ;
HAINES, JL ;
SACCHI, N ;
GUSELLA, JF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (16) :6032-6036
[5]  
DAVISSON M T, 1987, Genomics, V1, P213, DOI 10.1016/0888-7543(87)90047-4
[6]  
FEINBERG AP, 1984, ANAL BIOCHEM, V137, P266
[7]   GENETIC IDENTIFICATION OF ENDOGENOUS POLYTROPIC PROVIRUSES BY USING RECOMBINANT INBRED MICE [J].
FRANKEL, WN ;
STOYE, JP ;
TAYLOR, BA ;
COFFIN, JM .
JOURNAL OF VIROLOGY, 1989, 63 (09) :3810-3821
[8]   DECREASED HNF-1 GENE-EXPRESSION IN MICE HOMOZYGOUS FOR A 1.2-CENTIMORGAN DELETION ON CHROMOSOME-7 [J].
GONZALEZ, FJ ;
LIU, SY ;
KOZAK, CA ;
NEBERT, DW .
DNA AND CELL BIOLOGY, 1990, 9 (10) :771-776
[9]  
Green EL, 1981, GENETICS PROBABILITY, P77
[10]   A POLYMORPHIC DNA MARKER GENETICALLY LINKED TO HUNTINGTONS-DISEASE [J].
GUSELLA, JF ;
WEXLER, NS ;
CONNEALLY, PM ;
NAYLOR, SL ;
ANDERSON, MA ;
TANZI, RE ;
WATKINS, PC ;
OTTINA, K ;
WALLACE, MR ;
SAKAGUCHI, AY ;
YOUNG, AB ;
SHOULSON, I ;
BONILLA, E ;
MARTIN, JB .
NATURE, 1983, 306 (5940) :234-238
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