CYTOKINES IN ALZHEIMERS-DISEASE

被引：63
作者：
ALTSTIEL, LD
SPERBER, K
机构：
[1] CUNY MT SINAI SCH MED, FISHBERG NEUROBIOL CTR, NEW YORK, NY 10029 USA
[2] VET ADM MED CTR, DEPT PSYCHIAT, BRONX, NY 10468 USA
[3] CUNY MT SINAI SCH MED, DEPT INTERNAL MED, DIV CLIN IMMUNOL, NEW YORK, NY 10029 USA
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1991年 / 15卷 / 04期
关键词：
BETA-AMYLOID PRECURSOR PROTEIN; CYTOKINE; GLIAL CELLS; INTERLEUKIN-6; INTERLEUKIN-1; NEURONAL CELLS;
D O I：
10.1016/0278-5846(91)90023-T
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
1. Human astrocytoma cells produced biologically active interleukin-6 when treated with a variety of agents including bacterial lipopolysaccharides, viruses, and interleukin-1. 2. Both human recombinant IL-6 and IL-6 produced by stimulated astrocytes promoted differentiation of cultured neuronal cells and reduced survival time in culture. 3. Interleukin-6 and interleukin-1 stimulated the synthesis of the Alzheimer's disease beta-amyloid precursor protein. 4. Cytokines may be involved in stimulation of dystrophic neuritic sprouting, neuronal death, and amyloid deposition noted in the brains of Alzheimer's disease patients.
引用
收藏
页码：481 / 495
页数：15
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