MATURATION OF CAFFEINE ELIMINATION IN INFANCY

被引：120
作者：
ARANDA, JV
COLLINGE, JM
ZINMAN, R
WATTERS, G
机构：
[1] MCGILL UNIV,DEPT PHARMACOL & THERAPEUT,ROCHE DEV PHARMACOL UNIT,MONTREAL H3C 3G1,QUEBEC,CANADA
[2] MCGILL UNIV,MONTREAL CHILDRENS HOSP,DEPT PAEDIAT,MONTREAL H3H 1P3,QUEBEC,CANADA
[3] MCGILL UNIV,MONTREAL CHILDRENS HOSP,DEPT NEUROL,MONTREAL H3H 1P3,QUEBEC,CANADA
来源：
ARCHIVES OF DISEASE IN CHILDHOOD | 1979年 / 54卷 / 12期
关键词：
D O I：
10.1136/adc.54.12.946
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The developmental changes in caffeine elimination were studied in 7 infants aged between 2/1/2 weeks and 6 months. Adult plasma clearance rate of caffeine was achieved at 3 to 4/1/2 months of age. Plasma half-life and elimination rate reached adult levels after 3 to 4/1/2 months and seemed to exceed adult capacity thereafter. No significant changes in apparent volume of distribution were noted. Our data provide some indication of the age in infancy when the low rates of caffeine elimination in the neonate increase to the adult rate.
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页码：946 / 949
页数：4
相关论文
共 28 条
[1]  
ALDRIDGE A, 1979, CLIN PHARMACOL THER, V25, P447
[2]   PHARMACOKINETIC PROFILE OF CAFFEINE IN THE PREMATURE NEWBORN-INFANT WITH APNEA [J].
ARANDA, JV ;
COOK, CE ;
GORMAN, W ;
COLLINGE, JM ;
LOUGHNAN, PM ;
OUTERBRIDGE, EW ;
ALDRIDGE, A ;
NEIMS, AH .
JOURNAL OF PEDIATRICS, 1979, 94 (04) :663-668
[3]   EFFICACY OF CAFFEINE IN TREATMENT OF APNEA IN LOW-BIRTH-WEIGHT INFANT [J].
ARANDA, JV ;
GORMAN, W ;
BERGSTEINSSON, H ;
GUNN, T .
JOURNAL OF PEDIATRICS, 1977, 90 (03) :467-472
[4]   PHARMACOKINETIC ASPECTS OF THEOPHYLLINE IN PREMATURE NEWBORNS [J].
ARANDA, JV ;
SITAR, DS ;
PARSONS, WD ;
LOUGHNAN, PM ;
NEIMS, AH .
NEW ENGLAND JOURNAL OF MEDICINE, 1976, 295 (08) :413-416
[5]   PHARMACOKINETIC DISPOSITION OF CAFFEINE IN PREMATURE NEONATES WITH APNEA [J].
ARANDA, JV ;
GORMAN, W ;
OUTERBRIDGE, EW ;
NEIMS, AH .
PEDIATRIC RESEARCH, 1977, 11 (04) :414-414
[6]   HEPATIC MICROSOMAL DRUG OXIDATION AND ELECTRON-TRANSPORT IN NEWBORN-INFANTS [J].
ARANDA, JV ;
MACLEOD, SM ;
RENTON, KW ;
EADE, NR .
JOURNAL OF PEDIATRICS, 1974, 85 (04) :534-542
[7]   METABOLISM OF THEOPHYLLINE TO CAFFEINE IN PREMATURE NEWBORN-INFANTS [J].
BORY, C ;
BALTASSAT, P ;
PORTHAULT, M ;
BETHENOD, M ;
FREDERICH, A ;
ARANDA, JV .
JOURNAL OF PEDIATRICS, 1979, 94 (06) :988-993
[8]   PHYSIOLOGICAL DISPOSITION OF CAFFEINE [J].
BURG, AW .
DRUG METABOLISM REVIEWS, 1975, 4 (02) :199-228
[9]  
COOK CE, 1976, J PHARMACOL EXP THER, V199, P679
[10]  
CORNISH HH, 1957, J BIOL CHEM, V228, P315
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