CATABOLISM OF CALCITONIN GENE-RELATED PEPTIDE AND SUBSTANCE-P BY NEUTRAL ENDOPEPTIDASE

被引：94
作者：
KATAYAMA, M
NADEL, JA
BUNNETT, NW
DIMARIA, GU
HAXHIU, M
BORSON, DB
机构：
[1] UNIV CALIF SAN FRANCISCO,CARDIOVASC RES INST,BOX 0911,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,DEPT SURG,SAN FRANCISCO,CA 94143
[4] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143
来源：
PEPTIDES | 1991年 / 12卷 / 03期
关键词：
ENKEPHALINASE; CALLA; CD10; NEUTRAL METALLOENDOPEPTIDASE; EC-342411; PEPTIDASE INHIBITORS; PEPTIDASES; ENZYME KINETICS; HPLC;
D O I：
10.1016/0196-9781(91)90102-U
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calcitonin gene-related peptide (CGRP) and substance P (SP) are released from sensory nerves upon exposure to irritating stimuli. Neutral endopeptidase (NEP), a membrane-bound peptidase, cleaves many peptides including SP, thereby limiting their biological actions. Recombinant NEP cleaved CGRP1 approximately 88-fold less rapidly than it cleaved SP. The slow cleavage by NEP of CGRP compared to SP suggests that this enzyme is likely to have weaker physiologic effects on CGRP than have been demonstrated for SP.
引用
收藏
页码：563 / 567
页数：5
相关论文
共 40 条
[1]   NEUTRAL ENDOPEPTIDASE AND NEUROGENIC INFLAMMATION IN RATS WITH RESPIRATORY-INFECTIONS [J].
BORSON, DB ;
BROKAW, JJ ;
SEKIZAWA, K ;
MCDONALD, DM ;
NADEL, JA .
JOURNAL OF APPLIED PHYSIOLOGY, 1989, 66 (06) :2653-2658
[2]   ENKEPHALINASE INHIBITORS POTENTIATE SUBSTANCE P-INDUCED SECRETION OF (SO4)-S-35-MACROMOLECULES FROM FERRET TRACHEA [J].
BORSON, DB ;
CORRALES, R ;
VARSANO, S ;
GOLD, M ;
VIRO, N ;
CAUGHEY, G ;
RAMACHANDRAN, J ;
NADEL, JA .
EXPERIMENTAL LUNG RESEARCH, 1987, 12 (01) :21-36
[3]  
BORSON DB, 1986, PHYSIOLOGIST, V29, P174
[4]   INTERACTIONS BETWEEN THE TACHYKININS AND CALCITONIN GENE-RELATED PEPTIDE LEAD TO THE MODULATION OF EDEMA FORMATION AND BLOOD-FLOW IN RAT SKIN [J].
BRAIN, SD ;
WILLIAMS, TJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1989, 97 (01) :77-82
[5]   CALCITONIN GENE-RELATED PEPTIDE IS A POTENT VASODILATOR [J].
BRAIN, SD ;
WILLIAMS, TJ ;
TIPPINS, JR ;
MORRIS, HR ;
MACINTYRE, I .
NATURE, 1985, 313 (5997) :54-56
[6]   METABOLISM OF GASTRIN AND CHOLECYSTOKININ BY ENDOPEPTIDASE 24.11 FROM THE PIG STOMACH [J].
BUNNETT, NW ;
DEBAS, HT ;
TURNER, AJ ;
KOBAYASHI, R ;
WALSH, JH .
AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (05) :G676-G684
[7]   CGRP STIMULATES THE RELEASE OF PRO-SOMATOSTATIN-DERIVED PEPTIDES FROM THE GASTRIC FUNDUS [J].
BUNNETT, NW ;
HELTON, WS ;
DEBAS, HT ;
ENSINCK, JW .
AMERICAN JOURNAL OF PHYSIOLOGY, 1990, 258 (02) :G316-G319
[8]   ISOLATION OF ENDOPEPTIDASE-24.11 (EC 3.4.24.11, ENKEPHALINASE) FROM THE PIG STOMACH - HYDROLYSIS OF SUBSTANCE-P, GASTRIN-RELEASING PEPTIDE 10, [LEU5] ENKEPHALIN, AND [MET5] ENKEPHALIN [J].
BUNNETT, NW ;
TURNER, AJ ;
HRYSZKO, J ;
KOBAYASHI, R ;
WALSH, JH .
GASTROENTEROLOGY, 1988, 95 (04) :952-957
[9]   NEUTRAL ENDOPEPTIDASE INHIBITORS POTENTIATE SUBSTANCE P-INDUCED CONTRACTION IN GUT SMOOTH-MUSCLE [J].
DJOKIC, TD ;
SEKIZAWA, K ;
BORSON, DB ;
NADEL, JA .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (01) :G39-G43
[10]   NEUTRAL ENDOPEPTIDASE MODULATES NEUROTENSIN-INDUCED AIRWAY CONTRACTION [J].
DJOKIC, TD ;
DUSSER, DJ ;
BORSON, DB ;
NADEL, JA .
JOURNAL OF APPLIED PHYSIOLOGY, 1989, 66 (05) :2338-2343
1234