INDUCTION OF NORMAL ULTRASTRUCTURE BY CGRP TREATMENT IN DYSGENIC MYOTUBES

被引：21
作者：
GARCIA, L
PINCONRAYMOND, M
ROMEY, G
CHANGEUX, JP
LAZDUNSKI, M
RIEGER, F
机构：
[1] CNRS,UPR 411,INST PHARMACOL MOLEC & CELLULAIRE,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE
[2] INSERM,U153,BIOL & PATHOL NEUROMUSCULAIRES GRP,F-06560 VALBONNE,FRANCE
[3] INST PASTEUR,UNITE NEUROBIOL MOLEC,F-75724 PARIS 15,FRANCE
[4] INST PASTEUR,DEPT BIOTECHNOL,CNRS,UNITE 041149,F-75724 PARIS 15,FRANCE
来源：
FEBS LETTERS | 1990年 / 263卷 / 01期
关键词：
Ca[!sup]2+[!/sup] channel; Calcitonin gene-related peptide; Excitation-contraction coupling; Muscle; Muscular dysgenesis; Triad;
D O I：
10.1016/0014-5793(90)80725-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The calcitonin gene-related peptide (CGRP) restores an apparant normal ultrastructure in mdg/mdg muscle cells in vitro, including a normal triadic organization which is known to be essential for excitation-contraction (E-C) coupling. However, neither slow L-type Ca2+ channel activity nor E-C coupling, which are absent in mdg/mdg muscle, were re-established. These observations suggest a potential role of CGRP (and also ofcAMP as the intracellular messenger) in the morphological development of the muscle fiber. © 1990.
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收藏
页码：147 / 152
页数：6
相关论文
共 27 条
[1]   A LETHAL MUTATION IN MICE ELIMINATES THE SLOW CALCIUM CURRENT IN SKELETAL-MUSCLE CELLS [J].
BEAM, KG ;
KNUDSON, CM ;
POWELL, JA .
NATURE, 1986, 320 (6058) :168-170
[2]   IN-VITRO STUDY OF NORMAL AND MUTANT MYOGENESIS IN MOUSE [J].
BOWDENES.F .
DEVELOPMENTAL BIOLOGY, 1972, 27 (03) :351-&
[3]   VOLTAGE SENSORS OF THE FROG SKELETAL-MUSCLE MEMBRANE REQUIRE CALCIUM TO FUNCTION IN EXCITATION CONTRACTION COUPLING [J].
BRUM, G ;
FITTS, R ;
PIZARRO, G ;
RIOS, E .
JOURNAL OF PHYSIOLOGY-LONDON, 1988, 398 :475-505
[4]   CALCITONIN GENE-RELATED PEPTIDE, A PEPTIDE PRESENT IN SPINAL-CORD MOTONEURONS, INCREASES THE NUMBER OF ACETYLCHOLINE-RECEPTORS IN PRIMARY CULTURES OF CHICK-EMBRYO MYOTUBES [J].
FONTAINE, B ;
KLARSFELD, A ;
HOKFELT, T ;
CHANGEUX, JP .
NEUROSCIENCE LETTERS, 1986, 71 (01) :59-65
[5]  
GLUECKSOHNWAELS.S, 1963, SCIENCE, V142, P1269, DOI 10.1126/science.142.3597.1269
[6]   IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES [J].
HAMILL, OP ;
MARTY, A ;
NEHER, E ;
SAKMANN, B ;
SIGWORTH, FJ .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02) :85-100
[7]   COEXISTENCE OF NEURONAL MESSENGERS - AN OVERVIEW [J].
HOKFELT, T ;
HOLETS, VR ;
STAINES, W ;
MEISTER, B ;
MELANDER, T ;
SCHALLING, M ;
SCHULTZBERG, M ;
FREEDMAN, J ;
BJORKLUND, H ;
OLSON, L ;
LINDH, B ;
ELFVIN, LG ;
LUNDBERG, JM ;
LINDGREN, JA ;
SAMUELSSON, B ;
PERNOW, B ;
TERENIUS, L ;
POST, C ;
EVERITT, B ;
GOLDSTEIN, M .
PROGRESS IN BRAIN RESEARCH, 1986, 68 :33-70
[8]   PURIFIED RYANODINE RECEPTOR OF SKELETAL-MUSCLE SARCOPLASMIC-RETICULUM FORMS CA-2+-ACTIVATED OLIGOMERIC CA-2+ CHANNELS IN PLANAR BILAYERS [J].
HYMEL, L ;
INUI, M ;
FLEISCHER, S ;
SCHINDLER, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (02) :441-445
[9]  
IMAGAWA T, 1987, J BIOL CHEM, V262, P16636
[10]  
KNUDSON CM, 1989, J BIOL CHEM, V264, P1345
123