Intramyocellular fat storage in metabolic diseases

被引：26

作者：

Laurens, Claire ^{[2
,3
]}

Moro, Cedric ^{[1
,2
]}

机构：

[1] CHU Rangueil, INSERM, Inst Malad Metab & Cardiovasc, UMR 1048, BP 84225,1 Ave Jean Poulhes, F-31432 Toulouse 4, France

[2] Univ Toulouse 3, UMR1048, Toulouse, France

[3] INSERM, Inst Metab & Cardiovasc Dis, UMR1048, Obes Res Lab, Toulouse, France

来源：

HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION | 2016年 / 26卷 / 01期

关键词：

ectopic lipids; IMTG; lipotoxicity; skeletal muscle; type; 2; diabetes;

D O I：

10.1515/hmbci-2015-0045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past decades, obesity and its metabolic co-morbidities such as type 2 diabetes (T2D) developed to reach an endemic scale. However, the mechanisms leading to the development of T2D are still poorly understood. One main predictor for T2D seems to be lipid accumulation in "non-adipose" tissues, best known as ectopic lipid storage. A growing body of data suggests that these lipids may play a role in impairing insulin action in metabolic tissues, such as liver and skeletal muscle. This review aims to discuss recent literature linking ectopic lipid storage and insulin resistance, with emphasis on lipid deposition in skeletal muscle. The link between skeletal muscle lipid content and insulin sensitivity, as well as the mechanisms of lipid-induced insulin resistance and potential therapeutic strategies to alleviate lipotoxic lipid pressure in skeletal muscle will be discussed.

引用

页码：43 / 52

页数：10

共 99 条

[1] Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance Another Paradox in Endurance-Trained Athletes? [J].

Amati, Francesca ;

Dube, John J. ;

Alvarez-Carnero, Elvis ;

Edreira, Martin M. ;

Chomentowski, Peter ;

Coen, Paul M. ;

Switzer, Galen E. ;

Bickel, Perry E. ;

Stefanovic-Racic, Maja ;

Toledo, Frederico G. S. ;

Goodpaster, Bret H. .

DIABETES, 2011, 60 (10) :2588-2597

[2] Characterization of adipocytes derived from fibro/adipogenic progenitors resident in human skeletal muscle [J].

Arrighi, N. ;

Moratal, C. ;

Clement, N. ;

Giorgetti-Peraldi, S. ;

Peraldi, P. ;

Loubat, A. ;

Kurzenne, J-Y ;

Dani, C. ;

Chopard, A. ;

Dechesne, C. A. .

CELL DEATH & DISEASE, 2015, 6 :e1733-e1733

[3] High-Fat Diet-Mediated Lipotoxicity and Insulin Resistance Is Related to Impaired Lipase Expression in Mouse Skeletal Muscle [J].

Badin, Pierre-Marie ;

Vila, Isabelle K. ;

Louche, Katie ;

Mairal, Aline ;

Marques, Marie-Adeline ;

Bourlier, Virginie ;

Tavernier, Genevieve ;

Langin, Dominique ;

Moro, Cedric .

ENDOCRINOLOGY, 2013, 154 (04) :1444-1453

[4] Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58 [J].

Badin, Pierre-Marie ;

Loubiere, Camille ;

Coonen, Maarten ;

Louche, Katie ;

Tavernier, Genevieve ;

Bourlier, Virginie ;

Mairal, Aline ;

Rustan, Arild C. ;

Smith, Steven R. ;

Langin, Dominique ;

Moro, Cedric .

JOURNAL OF LIPID RESEARCH, 2012, 53 (05) :839-848

[5] Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans [J].

Badin, Pierre-Marie ;

Louche, Katie ;

Mairal, Aline ;

Liebisch, Gerhard ;

Schmitz, Gerd ;

Rustan, Arild C. ;

Smith, Steven R. ;

Langin, Dominique ;

Moro, Cedric .

DIABETES, 2011, 60 (06) :1734-1742

[6] Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans [J].

Bergman, B. C. ;

Hunerdosse, D. M. ;

Kerege, A. ;

Playdon, M. C. ;

Perreault, L. .

DIABETOLOGIA, 2012, 55 (04) :1140-1150

[7] Ceramides as modulators of cellular and whole-body metabolism [J].

Bikman, Benjamin T. ;

Summers, Scott A. .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (11) :4222-4230

[8] Intermuscular Adipose Tissue (IMAT): Association With Other Adipose Tissue Compartments and Insulin Sensitivity [J].

Boettcher, Michael ;

Machann, Juergen ;

Stefan, Norbert ;

Thame, Claus ;

Haering, Hans-Ulrich ;

Claussen, Claus D. ;

Fritsche, Andreas ;

Schick, Fritz .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2009, 29 (06) :1340-1345

[9] The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria [J].

Bosma, Madeleen ;

Minnaard, Ronnie ;

Sparks, Lauren M. ;

Schaart, Gert ;

Losen, Mario ;

de Baets, Marc H. ;

Duimel, Hans ;

Kersten, Sander ;

Bickel, Perry E. ;

Schrauwen, Patrick ;

Hesselink, Matthijs K. C. .

HISTOCHEMISTRY AND CELL BIOLOGY, 2012, 137 (02) :205-216

[10] Reduced Skeletal Muscle Oxidative Capacity and Elevated Ceramide but not Diacylglycerol Content in Severe Obesity [J].

Coen, P. M. ;

Hames, K. C. ;

Leachman, E. M. ;

DeLany, J. P. ;

Ritov, V. B. ;

Menshikova, E. V. ;

Dube, J. J. ;

Stefanovic-Racic, M. ;

Toledo, F. G. S. ;

Goodpaster, B. H. .

OBESITY, 2013, 21 (11) :2362-2371

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