GENETIC-MAPPING OF 3 HUMAN HOMOLOGS OF MURINE T-COMPLEX GENES LOCALIZES TCP10 TO 6Q27, 15 CM DISTAL TO TCP1 AND PLG

被引：13
作者：
BLANCHE, H
WRIGHT, LG
VERGNAUD, G
DEGOUYON, B
LAUTHIER, V
SILVER, LM
DAUSSET, J
CANN, HM
SPIELMAN, RS
机构：
[1] CTR ETUD POLYMORPHISME HUMAIN,27 RUE JULIETTE DODU,F-75010 PARIS,FRANCE
[2] UNIV PENN,SCH MED,DEPT HUMAN GENET,PHILADELPHIA,PA 19104
[3] CTR ETUD BOUCHET,F-91710 VERT LE PETIT,FRANCE
[4] PRINCETON UNIV,DEPT MOLEC BIOL,PRINCETON,NJ 08544
来源：
GENOMICS | 1992年 / 12卷 / 04期
关键词：
D O I：
10.1016/0888-7543(92)90317-L
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Human homologues of mouse t-complex genes have been cloned and localized physically to chromosome 6p or 6q. TCP1, TCP10, and PLG are human homologues of genes located in the proximal portion of the t-complex on mouse chromosome 17. We present here results of genetic mapping of these human t-complex homologues previously localized to 6q25-q27, 6q21-q27, and 6q26-q27, respectively, by physical techniques. TCP1 and PLG do not recombine with each other and are separated from TCP10 by about 15 cM, while the corresponding mouse genes are no more than 4 cM apart. Genetic mapping with markers well localized cytogenetically places TCP1 and PLG proximal to TCP10 and localizes the latter to the cytogenetic band 6q27. It is likely that the organization of human t-complex homologues on 6q is similar to that of t haplotypes rather than that of wildtype murine chromosome 17. © 1992.
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页码：826 / 828
页数：3
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