RENIN-ACTIVATION BY KALLIKREIN - EVIDENCE FOR ALKALINE-ACTIVATION OF PLASMA-RENIN

被引：9
作者：
HUMMERICH, W
FELTKAMP, H
KONRADS, A
AHLMANN, P
BORNHOFEN, H
机构：
[1] Department of Internal Medicine II, University of Cologne
来源：
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1979年 / 9卷 / 06期
关键词：
kallikrein; Renin; renin‐activation; renin‐precursors;
D O I：
10.1111/j.1365-2362.1979.tb00911.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Abstract. Porcine pancreatic kallikrein leads to a significant activation of human plasma renin when incubated at pH 8·2. ‘Endogenous’ activation of plasma renin can be seen by incubation of plasmas at the same pH. Both ‘endogenous’ alkaline‐ and kallikrein‐activation of plasma renin can be inhibited by aprotinin. Both, kallikrein‐ and ‘endogenous’ alkaline activation of plasma renin are significantly correlated to cryo‐ and acid‐activation. We suggest that kallikrein‐ and ‘endogenous’ alkaline‐activation come close to the in vivo activation process. Copyright © 1979, Wiley Blackwell. All rights reserved
引用
收藏
页码：447 / 449
页数：3
相关论文
共 16 条
  • [1] AMUNDSEN E, 1974, CHEM BIOL KALLIKREIN, P215
  • [2] ATLAS SA, 1978, CIRC RES, V43, pI128
  • [3] ACTIVATION OF INACTIVE PLASMA-RENIN - EVIDENCE THAT BOTH CRYOACTIVATION AND ACID-ACTIVATION WORK BY LIBERATING A NEUTRAL SERINE PROTEASE FROM ENDOGENOUS INHIBITORS
    ATLAS, SA
    LARAGH, JH
    SEALEY, JE
    [J]. CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1978, 55 : S135 - S138
  • [4] OCCURRENCE OF BIG RENIN IN HUMAN PLASMA, AMNIOTIC-FLUID AND KIDNEY EXTRACTS
    DAY, RP
    LUETSCHER, JA
    GONZALES, CM
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1975, 40 (06) : 1078 - 1084
  • [5] Heimburger N, 1975, PROTEASES BIOL CONTR, p367 404
  • [6] IMPROVEMENT OF RENIN DETERMINATION IN HUMAN PLASMA USING A COMMONLY AVAILABLE RENIN STANDARD IN A RADIOIMMUNOLOGICAL METHOD
    HUMMERICH, W
    KRAUSE, DK
    [J]. KLINISCHE WOCHENSCHRIFT, 1975, 53 (12): : 559 - 569
  • [7] ACID-ACTIVATION AND CRYOACTIVATION OF RENIN IN HUMAN-PLASMA
    HUMMERICH, W
    KONRADS, A
    SCHRAPPE, M
    HELBER, A
    WAMBACH, G
    [J]. KLINISCHE WOCHENSCHRIFT, 1979, 57 (09): : 475 - 477
  • [8] HUMMERICH W, 1978, RADIOIMMUNOASSAY REN, P116
  • [9] Leckie B J, 1977, Adv Exp Med Biol, V95, P249
  • [10] ENDOGENOUS PROTEASE ACTIVATING PLASMA INACTIVE RENIN
    LECKIE, BJ
    [J]. CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1978, 55 : S133 - S134
12