PLEIOTROPIC MUTATIONS WITHIN 2 YEAST MITOCHONDRIAL CYTOCHROME GENES BLOCK MESSENGER-RNA PROCESSING

被引：86

作者：

CHURCH, GM

SLONIMSKI, PP

GILBERT, W

机构：

[1] CNRS,CTR GENET MOLEC,F-91190 GIF SUR YVETTE,FRANCE

[2] UNIV PIERRE & MARIE CURIE,F-91190 GIF-SUR-YVETTE,FRANCE

来源：

CELL | 1979年 / 18卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0092-8674(79)90233-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mRNAs from two yeast mitochondrial genes cob-box (cytochrome b) and oxi-3 (cytochrome oxidase 40,000 dalton subunit) are processed from large (7-10 kb) precursors. Certain mutations in each gene block the maturation of the RNAs from both genes at a variety of specific steps. The pleiotropic cytochrome b mutants seem to lack a functional trans-acting RNA required for the processing of both messengers. In contrast, the oxi-3 mutants may act by producing an activity that inhibits specific steps. © 1979.

引用

页码：1209 / 1215

页数：7

共 32 条

[1]

ALEXANDER NJ, 1979, J BIOL CHEM, V254, P2471

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