BENZO[A]PYRENE METABOLISM IN NEONATAL RAT-LIVER NUCLEI

被引：9

作者：

BRESNICK, E ^{[1
]}

CHUANG, AHL ^{[1
]}

BORNSTEIN, WA ^{[1
]}

机构：

[1] UNIV VERMONT, COLL MED, DEPT BIOCHEM, BURLINGTON, VT 05401 USA

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 24卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0009-2797(79)90107-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of neonatal rat liver to form benzo[a]pyrene oxidative metabolites is investigated along with relative mixed function oxidase effects. Exposed liver tissues form benzo[a]pyrene proximate carcinogens even in the presence of lower microsomal activity especially in the presence of an inducer such as methylcholanthrene. Quantitative differences between adult and neonatal DNA enzyme systems are suggested for alkylated DNA repair.

引用

页码：111 / 115

页数：5

共 28 条

[1] COMPARISON OF METABOLISM OF BENZO[ALPHA]PYRENE AND BINDING TO DNA CAUSED BY RAT-LIVER NUCLEI AND MICROSOMES [J].

ALEXANDROV, K ;

BROOKES, P ;

KING, HWS ;

OSBORNE, MR ;

THOMPSON, MH .

CHEMICO-BIOLOGICAL INTERACTIONS, 1976, 12 (3-4) :269-277

[2]

[Anonymous], 1974, MOL BIOL CANC, DOI DOI 10.1016/B978-0-12-147660-1.50017-X

[3] METABOLIC CONVERSION OF BENZO[ALPHA]PYRENE BY SYRIAN-HAMSTER LIVER-MICROSOMES AND BINDING OF METABOLITES TO DEOXYRIBONUCLEIC ACID [J].

BORGEN, A ;

DARVEY, H ;

CASTAGNO.N ;

CROCKER, TT ;

RASMUSSE.RE ;

WANG, IY .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (05) :502-506

[4] EPOXIDE HYDRASE ACTIVITY IN LIVER NUCLEI - HYDRATION OF BENZO[A]PYRENE-4,5-OXIDE AND STYRENE OXIDE [J].

BORNSTEIN, WA ;

CHUANG, H ;

BRESNICK, E ;

MUKHTAR, H ;

BEND, JR .

CHEMICO-BIOLOGICAL INTERACTIONS, 1978, 21 (2-3) :343-346

[5] NUCLEAR ARYL-HYDROCARBON HYDROXYLASE AND INTERACTION OF POLYCYCLIC-HYDROCARBONS WITH NUCLEAR COMPONENTS [J].

BRESNICK, E ;

VAUGHT, JB ;

CHUANG, AHL ;

STOMING, TA ;

BOCKMAN, D ;

MUKHTAR, H .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1977, 181 (01) :257-269

[6] NUCLEAR METABOLISM OF BENZO(A)PYRENE AND OF (+/-)-TRANS-7,8-DIHYDROXY-7,8,-DIHYDROBENZO(A)PYRENE - COMPARATIVE CHROMATOGRAPHIC ANALYSIS OF ALKYLATED DNA [J].

BRESNICK, E ;

STOMING, TA ;

VAUGHT, JB ;

THAKKER, DR ;

JERINA, DM .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1977, 183 (01) :31-37

[7]

CONNEY AH, 1967, PHARMACOL REV, V19, P317

[8]

FAHL WE, 1978, J BIOL CHEM, V253, P3106

[9] EFFECT OF PHENANTHRENE ON TUMOUR INDUCTION BY 3,4-BENZOPYRENE ADMINISTERED TO NEWLY BORN MICE [J].

GRANT, G ;

ROE, FJC .

BRITISH JOURNAL OF CANCER, 1963, 17 (02) :261-&

[10]

JENNETTE KW, BIOCH PHARMACOL

← 1 2 3 →