Biomarkers in critical illness: have we made progress?

被引：12

作者：

Honore, Patrick M. ^{[1
]}

Jacobs, Rita ^{[1
]}

Hendrickx, Inne ^{[1
]}

De Waele, Elisabeth ^{[1
]}

Van Gorp, Viola ^{[1
]}

Joannes-Boyau, Olivier ^{[2
]}

De Regt, Jouke ^{[1
]}

Boer, Willem ^{[3
]}

Spapen, Herbert D. ^{[1
]}

机构：

[1] VUB Univ, Univ Ziekenhuis Brussel, Intens Care Unit, 101 Laarbeeklaan, B-1090 Brussels, Belgium

[2] Univ Bordeaux 2, Intens Care Unit, Hop Haut Leveque, Bordeaux, France

[3] Ziekenhuis Oost Limburg, Intens Care Unit, Genk, Belgium

来源：

INTERNATIONAL JOURNAL OF NEPHROLOGY AND RENOVASCULAR DISEASE | 2016年 / 9卷

关键词：

biomarkers; acute kidney injury; sepsis; ARDS;

D O I：

10.2147/IJNRD.S113219

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Biomarkers have emerged as exemplary key players in translational medicine. Many have been assessed for timely recognition, early treatment, and adequate follow-up for a variety of pathologies. Biomarker sensitivity has improved considerably over the last years but specificity remains poor, in particular when two "marker-sensitive" conditions overlap in one patient. Biomarker research holds an enormous potential for diagnostic and prognostic purposes in postoperative and critically ill patients who present varying degrees of inflammation, infection, and concomitant (sub) acute organ dysfunction or failure. Despite a remarkable progress in development and testing, biomarkers are not yet ready for routine use at the bedside.

引用

页码：253 / 256

页数：4

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