GUILT BY ASSOCIATION - HLA-B27 AND ANKYLOSING-SPONDYLITIS

被引：378
作者：
BENJAMIN, R
PARHAM, P
机构：
[1] Department of Cell Biology, Stanford University, Stanford
来源：
IMMUNOLOGY TODAY | 1990年 / 11卷 / 04期
关键词：
D O I：
10.1016/0167-5699(90)90051-A
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The remarkable association between HLA-B27 and ankylosing spondylitis (AS) remains an enigma. While previous reviews have discussed the controversies surrounding the involvement of bacteria in the etiology of this disease and the sequence variability between subtypes of HLA-B27 (Ref. 3), concepts of disease mechanism remain ill-defined. In this article Richard Benjamin and Peter Parham synthesize new data on the structure and function of HLA class 1 molecules into possible mechanisms that might underly the pathogenesis of AS. © 1990.
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页码：137 / 142
页数：6
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