OCCURRENCE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-SPECIFIC CYTOLYTIC T-CELL ACTIVITY IN APPARENTLY UNINFECTED CHILDREN BORN TO HIV-1-INFECTED MOTHERS

被引：131

作者：

DEMARIA, A

CIRILLO, C

MORETTA, L

机构：

[1] IST NAZL RIC CANC,GENOA,ITALY

[2] UNIV TURIN,DIPARTIMENTO MED & ONCOL SPERIMENTALE,NOVARA,ITALY

来源：

JOURNAL OF INFECTIOUS DISEASES | 1994年 / 170卷 / 05期

关键词：

D O I：

10.1093/infdis/170.5.1296

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocyte (CTL) activity against different viral antigens, including env, gag/pol, and nef, was detected in peripheral blood lymphocytes of as many as 25% of uninfected children born to HIV-1-infected mothers. The relatively high frequency of this finding in uninfected, exposed children suggests that CTL-mediated immunity may play a key role in the control or even elimination of the virus. Further characterization of this natural model of potentially protective immunity could provide new insight and suggest further strategies for the development of HIV-1 vaccines.

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页码：1296 / 1299

页数：4

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