CA2+ BINDING OF LATENT TRANSFORMING GROWTH-FACTOR-BETA-1 BINDING-PROTEIN

被引：22
作者：
COLOSETTI, P
HELLMAN, U
HELDIN, CH
MIYAZONO, K
机构：
[1] Ludwig Institute/or Cancer Research, Biomedical Center, S-751 24 Uppsala
来源：
FEBS LETTERS | 1993年 / 320卷 / 02期
关键词：
TRANSFORMING GROWTH FACTOR-BETA; BINDING PROTEIN; EGF-LIKE REPEAT; CA2+ BINDING;
D O I：
10.1016/0014-5793(93)80079-A
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Latent transforming growth factor-beta1 binding protein (LTBP) is a constituent of the latent high molecular weight complex of TGF-beta1 in human platelets. In the present communication, we show that LTBP binds Ca2+ in its free form as well as in the latent TGF-beta1 complex. The binding of Ca2+ induces a structural change which protects the molecule against proteolysis and changes its elution position when analyzed by anion exchange chromatography. The in vitro activation of TGF-beta1 is not influenced by the presence of Ca2+. The possible significance of Ca2+ binding of LTBP is discussed.
引用
收藏
页码：140 / 144
页数：5
相关论文
共 50 条
[21]   TRANSFORMING GROWTH-FACTOR-BETA-1 - A LESION-ASSOCIATED CYTOKINE OF THE NERVOUS-SYSTEM [J].
KIEFER, R ;
STREIT, WJ ;
TOYKA, KV ;
KREUTZBERG, GW ;
HARTUNG, HP .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1995, 13 (3-4) :331-339
[22]   In situ expression of transforming growth factor-β1-3, latent transforming growth factor-β binding protein and tumor necrosis factor-α in liver tissue from patients with chronic hepatitis C [J].
Kinnman, N ;
Andersson, U ;
Hultcrantz, R .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2000, 35 (12) :1294-1300
[23]   Physicochemical Activation of Recombinant Latent Transforming Growth Factor-beta's 1, 2, and 3 [J].
Brownh, Peter D. ;
Wakefiel, Lalage M. ;
Levinson, Arthur D. ;
Sporn, Michael B. .
GROWTH FACTORS, 1990, 3 (01) :35-43
[24]   EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA-1 ON GROWTH-REGULATORY GENES IN TUMOR-DERIVED HUMAN ORAL KERATINOCYTES [J].
PATERSON, IC ;
PATEL, V ;
SANDY, JR ;
PRIME, SS ;
YEUDALL, WA .
BRITISH JOURNAL OF CANCER, 1995, 72 (04) :922-927
[25]   Abrogation of both short and long forms of latent transforming growth factor-β binding protein-1 causes defective cardiovascular development and is perinatally lethal [J].
Horiguchi, Masahito ;
Todorovic, Vesna ;
Hadjiolova, Krassimira ;
Weiskirchen, Ralf ;
Rifkin, Daniel B. .
MATRIX BIOLOGY, 2015, 43 :61-70
[26]   Transforming growth factor beta stimulation of biglycan gene expression is potentially mediated by Sp1 binding factors [J].
Heegaard, AM ;
Xie, ZJ ;
Young, MF ;
Nielsen, KL .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2004, 93 (03) :463-475
[27]   IDENTIFICATION OF GROWTH-HORMONE BINDING-PROTEIN IN RAT SERUM [J].
AMIT, T ;
BARKEY, RJ ;
BICK, T ;
HERTZ, P ;
YOUDIM, MBH ;
HOCHBERG, Z .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1990, 70 (02) :197-202
[28]   A ROLE OF THE LATENT TGF-BETA-1-BINDING PROTEIN IN THE ASSEMBLY AND SECRETION OF TGF-BETA-1 [J].
MIYAZONO, K ;
OLOFSSON, A ;
COLOSETTI, P ;
HELDIN, CH .
EMBO JOURNAL, 1991, 10 (05) :1091-1101
[29]   Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis [J].
Awwad, Khader ;
Hu, Jiong ;
Shi, Lei ;
Mangels, Nicole ;
Malik, Randa Abdel ;
Zippel, Nina ;
Fisslthaler, Beate ;
Eble, Johannes A. ;
Pfeilschifter, Josef ;
Popp, Ruediger ;
Fleming, Ingrid .
CARDIOVASCULAR RESEARCH, 2015, 106 (02) :284-294
[30]   RECEPTOR-BINDING OF TRANSFORMING GROWTH-FACTOR-BETA BY HUMAN FETAL ADRENAL-CELLS [J].
STANKOVIC, AK ;
PARKER, CR .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1995, 109 (02) :159-165
12345