Chlorpyrifos Induced Cardiotoxicity in Rats and the Protective Role of Quercetin and Catechin

被引：0

作者：

Bas, Hatice ^{[1
]}

Kalender, Yusuf ^{[2
]}

机构：

[1] Bozok Univ, Fac Arts & Sci, Dept Biol, Yozgat, Turkey

[2] Gazi Univ, Fac Arts & Sci, Dept Biol, Ankara, Turkey

来源：

GAZI UNIVERSITY JOURNAL OF SCIENCE | 2011年 / 24卷 / 03期

关键词：

Chlorpyrifos; Flavonoids; Antioxidant Enzymes; Histopathology; Heart;

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this study, chlorpyrifos, catechin, quercetin and catechin- or quercetin+chlorpyrifos were given to Wistar rats for 4 weeks. Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase ( SOD) and catalase (CAT); decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in heart compared to the control. In catechin- and quercetin+chlorpyrifos groups, we observed the protective effects of flavonoids on examining parameters. Light microscopic investigations revealed that chlorpyrifos induced histopathological alterations in heart. Milder histopathological changes were observed co-treated with catechin-or quercetin+chlorpyrifos. As a result, catechin and quercetin significantly reduce chlorpyrifos induced cardiotoxicity in rats, but they aren't protect completely.

引用

页码：387 / 395

页数：9

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