Chlorpyrifos Induced Cardiotoxicity in Rats and the Protective Role of Quercetin and Catechin

被引：0
|
作者：
Bas, Hatice [1 ]
Kalender, Yusuf [2 ]
机构：
[1] Bozok Univ, Fac Arts & Sci, Dept Biol, Yozgat, Turkey
[2] Gazi Univ, Fac Arts & Sci, Dept Biol, Ankara, Turkey
来源：
GAZI UNIVERSITY JOURNAL OF SCIENCE | 2011年 / 24卷 / 03期
关键词：
Chlorpyrifos; Flavonoids; Antioxidant Enzymes; Histopathology; Heart;
D O I：
暂无
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In this study, chlorpyrifos, catechin, quercetin and catechin- or quercetin+chlorpyrifos were given to Wistar rats for 4 weeks. Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase ( SOD) and catalase (CAT); decreased glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in heart compared to the control. In catechin- and quercetin+chlorpyrifos groups, we observed the protective effects of flavonoids on examining parameters. Light microscopic investigations revealed that chlorpyrifos induced histopathological alterations in heart. Milder histopathological changes were observed co-treated with catechin-or quercetin+chlorpyrifos. As a result, catechin and quercetin significantly reduce chlorpyrifos induced cardiotoxicity in rats, but they aren't protect completely.
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页码：387 / 395
页数：9
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