NICOTINE ENHANCES 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE NEUROTOXICITY

被引：49
作者：
BEHMAND, RA
HARIK, SI
机构：
[1] UNIV HOSP CLEVELAND,DEPT NEUROL,2074 ABINGTON RD,CLEVELAND,OH 44106
[2] CASE WESTERN RESERVE UNIV,CLEVELAND,OH 44106
来源：
JOURNAL OF NEUROCHEMISTRY | 1992年 / 58卷 / 02期
关键词：
CIGARETTE SMOKING; NICOTINE; PARKINSONS DISEASE; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE NEUROTOXICITY; NIGROSTRIATAL DOPAMINERGIC SYSTEM; NIGROSTRIATAL DEGENERATION;
D O I：
10.1111/j.1471-4159.1992.tb09786.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epidemiologic evidence of an inverse relationship between cigarette smoking and Parkinson's disease suggests that a component of cigarette smoke protects against nigrostriatal degeneration. Nicotine, a major component of cigarette smoke, is similar in chemical structure to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and is metabolized in part by the same enzymes that detoxify MPTP. We investigated the effect of chronic nicotine on MPTP neurotoxicity in two strains of mice and found that nicotine increases rather than decreases MPTP toxicity. These results are not compatible with the hypothesis that nicotine is that component of cigarette smoke that protects against nigrostriatal degeneration, at least in the MPTP experimental model of Parkinson's disease.
引用
收藏
页码：776 / 779
页数：4
相关论文
共 28 条
[1]   CIGARETTE-SMOKING AND PARKINSONS-DISEASE [J].
BARON, JA .
NEUROLOGY, 1986, 36 (11) :1490-1496
[2]   ATTENUATION OF 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-INDUCED NEUROTOXICITY BY TOBACCO-SMOKE [J].
CARR, LA ;
ROWELL, PP .
NEUROPHARMACOLOGY, 1990, 29 (03) :311-314
[3]  
DIMONTE D, 1988, DRUG METAB DISPOS, V16, P250
[4]   EFFECT OF NICOTINE PRETREATMENT ON STRIATAL DOPAMINERGIC SYSTEM IN RATS [J].
FUNG, YK ;
LAU, YS .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 32 (01) :221-226
[5]   CHRONIC ADMINISTRATION OF NICOTINE FAILS TO ALTER THE MPTP-INDUCED NEUROTOXICITY IN MICE [J].
FUNG, YK ;
FISKE, LA ;
LAU, YS .
GENERAL PHARMACOLOGY, 1991, 22 (04) :669-672
[6]   REGULATION OF DOPAMINE RELEASE BY PRESYNAPTIC NICOTINIC RECEPTORS IN RAT STRIATAL SLICES - EFFECT OF NICOTINE IN A LOW CONCENTRATION [J].
GIORGUIEFFCHESSELET, MF ;
KEMEL, ML ;
WANDSCHEER, D ;
GLOWINSKI, J .
LIFE SCIENCES, 1979, 25 (14) :1257-1262
[7]   VALIDATION OF SELF-REPORTED SMOKING-BEHAVIOR - BIOCHEMICAL ANALYSES OF COTININE AND THIOCYANATE [J].
HALEY, NJ ;
AXELRAD, CM ;
TILTON, KA .
AMERICAN JOURNAL OF PUBLIC HEALTH, 1983, 73 (10) :1204-1207
[8]   MONOAMINE NEUROTRANSMITTERS IN DIFFUSE REVERSIBLE FOREBRAIN ISCHEMIA AND EARLY RECIRCULATION - INCREASED DOPAMINERGIC ACTIVITY [J].
HARIK, SI ;
YOSHIDA, S ;
BUSTO, R ;
GINSBERG, MD .
NEUROLOGY, 1986, 36 (07) :971-976
[9]   NICOTINE PREFERENTIALLY STIMULATES DOPAMINE RELEASE IN THE LIMBIC SYSTEM OF FREELY MOVING RATS [J].
IMPERATO, A ;
MULAS, A ;
DICHIARA, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 132 (2-3) :337-338
[10]   CHRONIC NICOTINE TREATMENT PARTLY PROTECTS AGAINST THE 1-METHYL-4-PHENYL-2, 3, 6-TETRAHYDROPYRIDINE-INDUCED DEGENERATION OF NIGROSTRIATAL DOPAMINE NEURONS IN THE BLACK MOUSE [J].
JANSON, AM ;
FUXE, K ;
SUNDSTROM, E ;
AGNATI, LF ;
GOLDSTEIN, M .
ACTA PHYSIOLOGICA SCANDINAVICA, 1988, 132 (04) :589-591
123