AN EFFICIENT APPROACH TO BETA-OXOADIPATE DERIVATIVES AND GAMMA-OXO ACIDS BY THE REFORMATSKY REACTION OF ETHYL ALPHA-BROMOALKANOATES WITH SUCCINIC ANHYDRIDE

被引：0

作者：

SCHICK, H

LUDWIG, R

机构：

来源：

SYNTHESIS-STUTTGART | 1992年 / 04期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl 2-bromoalkanoates react with zinc and succinic anhydride in dimethylformamide forming 2-substituted 1-ethyl hydrogen 3-oxoadipates (hexanedioates) isolable in a yield of 56-78%. When subjected to decarboxylative saponification, they afford 4-oxoalkanoic acids in overall yields of 50-72%.

引用

页码：369 / 370

页数：2

共 18 条

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