QUINOBENE, A NEW POTENT ANTI-HIV AGENT

被引：14
|
作者：
GRUSZECKAKOWALIK, E [1 ]
HAUGWITZ, RD [1 ]
ZALKOW, LH [1 ]
机构：
[1] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 03期
关键词：
D O I：
10.1016/0006-291X(92)90459-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4′-diaminostilbene-2,2′-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound. The lithium and tetramethylammonium salts of Quinobene and its complexes with Cu(II), Zn(II), Mg(II) were also prepared. In vitro tests showed considerable activity of these compounds against HIV-1. © 1992.
引用
收藏
页码：1409 / 1417
页数：9
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