QUINOBENE, A NEW POTENT ANTI-HIV AGENT

被引：14

作者：

GRUSZECKAKOWALIK, E ^{[1
]}

HAUGWITZ, RD ^{[1
]}

ZALKOW, LH ^{[1
]}

机构：

[1] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)90459-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4′-diaminostilbene-2,2′-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound. The lithium and tetramethylammonium salts of Quinobene and its complexes with Cu(II), Zn(II), Mg(II) were also prepared. In vitro tests showed considerable activity of these compounds against HIV-1. © 1992.

引用

页码：1409 / 1417

页数：9

共 50 条

[31] Enantioselective total synthesis of the potent anti-HIV agent neotripterifordin. Reassignment of stereochemistry at C(16)
Corey, EJ
Liu, K
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (41) : 9929 - 9930
[32] Etravirine -: Anti-HIV agent reverse transcriptase inhibitor
Davies, SL
Castañer, J
Silvestre, JS
Bayés, M
DRUGS OF THE FUTURE, 2005, 30 (05) : 462 - 468
[33] Sulfur Metabolism in AIDS: Cystamine as an Anti-HIV Agent
Toohey, John I.
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2009, 25 (11) : 1057 - 1060
[34] Capravirine -: Anti-HIV agent -: Reverse transcriptase inhibitor
Sorbera, LA
Castañer, J
Bayés, M
DRUGS OF THE FUTURE, 2003, 28 (12) : 1149 - 1158
[35] PHYSICOCHEMICAL PROPERTIES OF CARBOVIR, A POTENTIAL ANTI-HIV AGENT
ANDERSON, BD
CHIANG, CY
JOURNAL OF PHARMACEUTICAL SCIENCES, 1990, 79 (09) : 787 - 790
[36] Characterization of cysteamine as a potential contraceptive anti-HIV agent
Anderson, RA
Feathergill, K
Kirkpatrick, R
Zaneveld, LJD
Coleman, KT
Spear, PG
Cooper, MD
Waller, DP
Thoene, JG
JOURNAL OF ANDROLOGY, 1998, 19 (01): : 37 - 49
[37] New developments in anti-HIV chemotherapy
De Clercq, E
PURE AND APPLIED CHEMISTRY, 2001, 73 (01) : 55 - 66
[38] DESIGN AND SYNTHESIS OF COSALANE, A NOVEL ANTI-HIV AGENT
GOLEBIEWSKI, WM
BADER, JP
CUSHMAN, M
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1993, 3 (08) : 1739 - 1742
[39] Total synthesis of anti-HIV agent chloropeptin I
Deng, HB
Jung, JK
Liu, T
Kuntz, KW
Snapper, ML
Hoveyda, AH
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (30) : 9032 - 9034
[40] Bevirimat - Anti-HIV agent viral maturation inhibitor
Dimeglumine, Bevirimat
DRUGS OF THE FUTURE, 2007, 32 (01) : 7 - 11

← 1 2 3 4 5 →