QUINOBENE, A NEW POTENT ANTI-HIV AGENT

被引：14

作者：

GRUSZECKAKOWALIK, E ^{[1
]}

HAUGWITZ, RD ^{[1
]}

ZALKOW, LH ^{[1
]}

机构：

[1] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,BETHESDA,MD 20892

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)90459-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A simple synthesis of the sulfonated azo dye Quinobene (3) and its derivatives, as well as the results of their evaluation in anti-HIV screening have been described. Thus, reacting the diazonium salt of 4,4′-diaminostilbene-2,2′-disulfonic acid with 8-hydroxyquinoline-5-sulfonic acid yielded the readily isolable title compound. The lithium and tetramethylammonium salts of Quinobene and its complexes with Cu(II), Zn(II), Mg(II) were also prepared. In vitro tests showed considerable activity of these compounds against HIV-1. © 1992.

引用

页码：1409 / 1417

页数：9

共 50 条

[1] PHARMACOLOGY AND SYNTHESIS OF DAURICHROMENIC ACID AS A POTENT ANTI-HIV AGENT
Bukhari, Syed Majid
Ali, Iftikhar
Zaidi, Asma
Iqbal, Naseem
Noor, Tayyaba
Mehmood, Rashad
Chishti, Muhammad Salman
Niaz, Basit
Rashid, Umer
Atif, Muhammad
ACTA POLONIAE PHARMACEUTICA, 2015, 72 (06): : 1059 - 1071
[2] New AZT conjugates as potent anti-HIV agents
You, ZQ
Lee, HJ
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2006, 25 (01): : 37 - 54
[3] KINETICS OF THE HYDROLYSIS OF 2',3'-DIDEOXYGUANOSINE - A POTENT ANTI-HIV AGENT
VANSCHEPDAEL, A
OSSEMBE, N
JIE, L
HERDEWIJN, P
ROETS, E
HOOGMARTENS, J
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1991, 73 (02) : 105 - 110
[4] HIV integrase inhibitors with nucleobase scaffolds: Discovery of a highly potent anti-HIV agent
Nair, V
Chi, G
Ptak, R
Neamati, N
JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (02) : 445 - 447
[5] Anonymous anti-HIV agent
Nature Medicine, 1998, 4 (4) : 371 - 371
[6] Anonymous anti-HIV agent
不详
NATURE MEDICINE, 1998, 4 (04) : 371 - 371
[7] Coral reefs provide potent new anti-HIV proteins
不详
MARINE POLLUTION BULLETIN, 2014, 83 (01) : 5 - 6
[8] New phorbol ester derivatives as potent anti-HIV agents
Li, Qi-Run
Cheng, Yung-Yi
Zhao, Lei
Huang, Xiao-Lei
Jiang, Xiao-Gang
Cui, Ya-Dong
Morris-Natschke, Susan L.
Goto, Masuo
Chen, Chin-Ho
Lee, Kuo-Hsiung
Chen, Dao-Feng
Zhang, Jian
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 50
[9] DEXTRAN SULFATE, A POTENT ANTI-HIV AGENT INVITRO HAVING SYNERGISM WITH ZIDOVUDINE
UENO, R
KUNO, S
LANCET, 1987, 1 (8546): : 1379 - 1379
[10] PENTOSAN POLYSULFATE, A SULFATED OLIGOSACCHARIDE, IS A POTENT AND SELECTIVE ANTI-HIV AGENT INVITRO
BABA, M
NAKAJIMA, M
SCHOLS, D
PAUWELS, R
BALZARINI, J
DECLERCQ, E
ANTIVIRAL RESEARCH, 1988, 9 (06) : 335 - 343

← 1 2 3 4 5 →