PHARMACOKINETICS OF ALPHA-DIHYDROERGOCRYPTINE IN RATS AFTER INTRAVENOUS AND ORAL-ADMINISTRATION

被引：0
作者：
GROGNET, JM
ISTIN, M
ZANOTTI, A
MAILLAND, F
COPPI, G
机构：
[1] CENS,DEPT RES IMAGERIE PHARMACOL & PHYSIOL,SERV PHARMACOL & IMMUNOL,F-91190 GIF SUR YVETTE,FRANCE
[2] POLI IND CHIM SPA,RES CTR,ROZZANO,ITALY
来源：
ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH | 1991年 / 41-2卷 / 07期
关键词：
ANTI-PARKINSONIAN DRUGS; CAS; 19467-62-0; ALPHA-DIHYDROERGOCRYPTINE; PHARMACOKINETICS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The pharmacokinetic properties of a-dihydroergocryptine methanesulphonate (a-DHEK, CAS 19467-62-0) were investigated in rat using a radioimmunoassay technique for nonmetabolized drug. a-DHEK, intravenously administered at the dose of 6 mg/kg, showed a plasma profile according to an open 3-compartment pharmacokinetic model with a long half-life (about 7.56 h). The kinetics of a-DHEK after oral administration (6 mg/kg) showed two peaks; the second peak at 8 h was probably due to an enterohepatic cycle. The disposition of a-DHEK consisted in a fast absorption and a slow elimination (t1/2el about 6.78 h). The a-DHEK was largely metabolized as results from the complex metabolite profile in body fluids and from very low urinary elimination of unchanged drug.
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页码：689 / 691
页数：3
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