TRANSCRIPTIONAL REGULATION OF MURINE NADP+-DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE-SYNTHETASE

被引：14
|
作者：
PERI, KG [1 ]
MACKENZIE, RE [1 ]
机构：
[1] MCGILL UNIV,DEPT BIOCHEM,3655 DRUMMOND ST,MONTREAL H3G 1Y6,QUEBEC,CANADA
来源：
FEBS LETTERS | 1991年 / 294卷 / 1-2期
关键词：
FOLATE; NADP+-DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE; TRIFUNCTIONAL ENZYME; MULTIFUNCTIONAL ENZYME; IGF-1; POSTTRANSCRIPTIONAL REGULATION;
D O I：
10.1016/0014-5793(91)81354-B
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cytosolic NADP+-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase is ubiquitously expressed in all mouse tissues and cell lines examined. Northern analyses of the RNA indicated that there is an extensive variation in the levels of mRNA in different tissues. However, the gene is refractory to induction by serum, phorbol esters or growth factors in cultured fibroblasts. The mRNA of the NADP+-dependent trifunctional enzyme is stabilized post-transcriptionally by insulin-like growth factor-1.
引用
收藏
页码：113 / 115
页数：3
相关论文
共 5 条
  • [1] Mammalian mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase derived from a trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase
    Patel, H
    Christensen, KE
    Mejia, N
    MacKenzie, RE
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2002, 403 (01) : 145 - 148
  • [2] NAD+-DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE-CYCLOHYDROLASE - DETECTION OF THE MESSENGER-RNA IN NORMAL MURINE TISSUE AND TRANSCRIPTIONAL REGULATION OF THE GENE IN CELL-LINES
    PERI, KG
    MACKENZIE, RE
    BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1171 (03) : 281 - 287
  • [3] NAD-DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE-METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE IS TARGETED TO THE CYTOPLASM IN INSECT-CELL LINES
    TREMBLAY, GB
    SOHI, SS
    RETNAKARAN, A
    MACKENZIE, RE
    FEBS LETTERS, 1995, 368 (01) : 177 - 182
  • [4] Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?
    Feng, Zichen
    An, Ning
    Yu, Fangfang
    Ma, Jun
    Li, Na
    Du, Yuhui
    Guo, Meng
    Xu, Kaihong
    Hou, Xiangbo
    Li, Zhiyuan
    Zhou, Guoyu
    Ba, Yue
    CHINESE MEDICAL JOURNAL, 2022, 135 (15) : 1846 - 1854
  • [5] NAD- and NADP-dependent mitochondrially targeted methylenetetrahydrofolate dehydrogenase-cyclohydrolases can rescue mthfd2 null fibroblasts
    Patel, H
    Di Pietro, E
    Mejia, N
    MacKenzie, RE
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2005, 442 (01) : 133 - 139
1