THE NONSPECIFICITY OF SPECIFIC NITRIC-OXIDE SYNTHASE INHIBITORS

被引：167

作者：

PETERSON, DA ^{[1
]}

PETERSON, DC ^{[1
]}

ARCHER, S ^{[1
]}

WEIR, EK ^{[1
]}

机构：

[1] UNIV MINNESOTA,MINNEAPOLIS,MN 55417

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91266-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

L-NAME (Nw-Nitro-L-arginine methylester) and L-NMMA (NG-Monomethyl-L-arginine, monoacetate) are used widely as nitric oxide (NO) synthase inhibitors. Because of their functional groups (alcohols, amines and carboxylates), it appeared that they could interact with iron in a variety of systems. Using three in vitro models we observed these two compounds had inhibitory effects on cytochrome C reduction by ferrous iron, by ferrous iron accelerated by an unsaturated fatty acid or by epinephrine. This suggests that L-NAME and L-NMMA could have effects in iron containing systems found intracellularly apart from their inhibition of (NO) synthesis. © 1992.

引用

页码：797 / 801

页数：5

共 11 条

[1] ENDOTHELIUM-DERIVED NITRIC-OXIDE RELAXES NONVASCULAR SMOOTH-MUSCLE [J].