DOPAMINE-INDUCED CONTRACTILE RESPONSES OF THE RAT ANOCOCCYGEUS MUSCLE
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作者:
OLIVEIRA, AM
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OLIVEIRA, AM
BENDHACK, LM
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BENDHACK, LM
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来源:
ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE
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1992年
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316卷
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中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
In the rat anococcygeus muscle both dopamine and noradrenaline induced concentration-dependent contractile responses. The alpha-1-antagonist prazosin inhibited both dopamine and noradrenaline responses, whereas the alpha-2-antagonist yohimbine influenced noradrenaline-mediated responses only. The concentration-effect curves for dopamine were shifted to the right in presence of cocaine or after treatment with reserpine and alpha-methyl-p-tyrosine. When the tissues were previously exposed to 6-hydroxydopamine, the tyramine-induced contractile effect was abolished. Dopamine-induced concentration-effect curves were markedly shifted to the right. Treatment with 6-hydroxydopamine and reserpine did not modify the concentration-effect curves to noradrenaline. Our results indicate that dopamine has a dual effect: a partial effect due to an indirect sympathomimetic action and a partial effect due to the interaction with postjunctional receptors.