REACTIVITY OF ISOLATED CANINE BRONCHUS AND PULMONARY BLOOD-VESSELS TO AUTONOMIC, AUTACOID AGENTS AND ANTIGEN

被引：14

作者：

CHAND, N ^{[1
]}

EYRE, P ^{[1
]}

机构：

[1] UNIV GUELPH,DEPT BIOMED SCI,PHARMACOL LAB,GUELPH N1G 2W1,ONTARIO,CANADA

来源：

AGENTS AND ACTIONS | 1979年 / 9卷 / 01期

关键词：

D O I：

10.1007/BF02024088

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Adult dogs were sensitized to horse plasma. Reactivity of isolated bronchus and pulmonary blood vessels to antigen and some selected autonomic and autacoid agents were studied. Pulmonary veins contracted to bradykinin, 5-HT, PGF2α, PGE2, histamine, carbachol and antigen (Schultz-Dale reaction). Pulmonary arterial strips contracted to 5-HT and histamine, but only weakly to horse plasma. Bronchial strips contracted to carbachol, 5-HT, histamine and horse plasma, relaxed to isoprenaline, PGE1 and PGE2. Subsequent antigen challenge produced 'desensitization'. Allowing the tissues to 'rest' for 1 and 2 h resulted in partial 'recovery' of the anaphylactic response. This investigation suggests that the contractions of sensitized pulmonary vein and bronchus to specific antigen may contribute to the patho-physiology of pulmonary hypersensitivity in dogs. © 1979 Birkhäuser-Verlag.

引用

页码：4 / 8

页数：5

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