SEXUAL DIMORPHIC PORCINE PITUITARY-RESPONSE TO GROWTH HORMONE-RELEASING HORMONE

被引：5
|
作者：
HEIMAN, ML [1 ]
SURFACE, PL [1 ]
MOWREY, DH [1 ]
DIMARCHI, RD [1 ]
机构：
[1] ELI LILLY INT CORP,LILLY RES LAB,INDIANAPOLIS,IN 46285
来源：
DOMESTIC ANIMAL ENDOCRINOLOGY | 1990年 / 7卷 / 02期
关键词：
D O I：
10.1016/0739-7240(90)90033-V
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
The aim of this study was to compare growth hormone (GH) response of barrows and gilts to porcine growth hormone-releasing hormone (pGRH) at the pituitary level. Anterior pituitary cells from barrows and gilts responded to pGRH in a dose-dependent manner. The median effective pGRH concentration (EC50) which stimulated GH release from cells of barrows was greater (P < .05) than that for cells obtained from intact female siblings. Maximal pGRH mediated GH secretion from barrows was not different (P > 0.05) than that from gilt stimulated cells. These data demonstrate that somatotrophs of growing peripubertal gilts are more responsive to pGRH stimulation than are cells from their castrated male siblings. This difference could be caused by castration of the neonatal male. © 1990.
引用
收藏
页码：273 / 276
页数：4
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